Navegando por Autor "Freire, Mariana"
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Artigo "Clock dial pattern", a radiologic clue to neuro-chikungunya diagnosis: a case series(Georg Thieme Verlag KG, 2024-01) Fraiman, Pedro Henrique Almeida; Freire, Mariana; Fernandes, Bruno; Mangueira, Felipe Palitot Alves; Mota, Nathalia Louise Gomes do Rosario Alves da; Sequerra, Eduardo Bouth; Santos, Glauco Igor Viana dos; Dourado Junior, Mario Emilio Teixeira; Godeiro Júnior, Clécio de Oliveira; Moreira-Neto, ManuelBackground: Chikungunya is a mosquito-borne disease caused by the chikungunya virus (CHIKV) and can lead to neurological complications in severe cases. Objective: This study examined neuroimaging patterns in chikungunya cases during two outbreaks in Brazil to identify specific patterns for diagnosis and treatment of neuro-chikungunya. Methods: Eight patients with confirmed chikungunya and neurological involvement were included. Clinical examinations and MRI scans were performed, and findings were analyzed by neuroradiologists. Data on age, sex, neurological symptoms, diagnostic tests, MRI findings, and clinical outcomes were recorded. Results: Patients showed different neuroimaging patterns. Six patients exhibited a "clock dial pattern" with hyperintense dotted lesions in the spinal cord periphery. One patient had thickening and enhancement of anterior nerve roots. Brain MRI revealed multiple hyperintense lesions in the white matter, particularly in the medulla oblongata, in six patients. One patient had a normal brain MRI. Conclusion: The "clock dial pattern" observed in spinal cord MRI may be indicative of chikungunya-related nervous system lesions. Isolated involvement of spinal cord white matter in chikungunya can help differentiate it from other viral infections. Additionally, distinct brainstem involvement in chikungunya-associated encephalitis, particularly in the rostral region, sets it apart from other arboviral infections. Recognizing these neuroimaging patterns can contribute to early diagnosis and appropriate management of neuro-chikungunyaArtigo Hemorrhagic stroke and COVID-19 infection: coincidence or causality?(Elsevier, 2020-12) Godeiro Junior, Clécio de Oliveira; Freire, Mariana; Moreira Neto, Manuel; Fraiman, Pedro Henrique Almeida; 0000-0002-4312-1633Amyloid Protein Precursor gene duplication is a rare cause of early-onset Alzheimer's disease that can be associated with Cerebral Amyloid Angiopathy. This condition predisposes cerebrovascular events, specifically, intracerebral hemorrhagic stroke. This report describes a case of first-time intracerebral hemorrhage in a patient with APP gene duplication during SARS-CoV-2 infection, a typically pro-thrombotic and pro-inflammatory condition, as a possible trigger for this condition.