Navegando por Autor "Freire, Fernanda Lambert de Andrade"
Agora exibindo 1 - 8 de 8
- Resultados por página
- Opções de Ordenação
Artigo Biomarkers of zinc and copper status and associated factors in outpatients with ischemic and non-ischemic heart failure(Journal of the American Nutrition Association, 2022-02) Evangelista, Karine Cavalcanti Maurício de Sena; Freire, Fernanda Lambert de Andrade; Komatsu, Raquel Costa Silva Dantas; Lira, Niethia Regina Dantas de; Diniz, Rosiane Viana Zuza; Lima, Severina Carla Vieira Cunha; Barbosa, Fernando; Pedrosa, Lucia Fatima CamposBackground: Few studies have explored the impact of ischemic and non-ischemic etiologies of heart failure and other factors associated with heart failure on zinc and copper status. This study examined zinc and copper status in 80 outpatients with ischemic (n ¼ 36) and non-ischemic (n ¼ 44) heart failure and associations with biodemographic, clinical, biochemical, and nutritional parameters. Materials: Biomarkers of plasma zinc and copper, copper-zinc ratio, 24-h urinary zinc excretion, ceruloplasmin, and dietary intake of zinc and copper were assessed. Plasma zinc and copper and urinary zinc were measured by inductively coupled plasma mass spectrometry (ICP-MS). Results: Patients with ischemic heart failure showed lower dietary zinc intake and higher dietary copper intake (both p ¼ 0.02). Zinc and copper in plasma, copper-zinc ratio, ceruloplasmin, and 24-h urinary zinc excretion showed no statistical differences between the groups (all p 0.05). An inverse association was found between age (b ¼0.001; p ¼ 0.005) and the use of diuretics (b ¼ -0.047; p ¼ 0.013) and plasma zinc. Copper levels in plasma (b = 0.001; p < 0.001), and albumin (b ¼ 0.090; p<0.001) were directly associated with plasma zinc. A positive association was found between ceruloplasmin (b ¼ 0.011; p < 0.001), gamma-glutamyl transferase (b ¼ 0.001; p < 0.001), albumin (b ¼ 0.077; p ¼ 0.001), and high-sensitivity c-reactive protein (b ¼ 0.001; p ¼ 0.024) and plasma copper. Conclusion: Zinc and copper biomarkers in clinically stable patients with heart failure did not seem to be responsive to the differences in zinc and copper intake observed in this study, regardless of heart failure etiology. The predictors of plasma zinc and copper levels related to oxidative stress and inflammation should be monitored in heart failure clinical practiceArtigo Biomarkers of zinc and copper status and associated factors in outpatients with ischemic and non-ischemic heart failure(Journal of the american college of nutrition, 2022) Lima, Severina Carla Vieira Cunha; Freire, Fernanda Lambert de Andrade; Komatsu, Raquel Costa Silva Dantas; Lira, Niethia Regina Dantas de; Diniz, Rosiane Viana Zuza; Barbosa Junior, Fernando; Pedrosa, Lucia Fatima Campos; Evangelista, Karine Cavalcanti Mauricio Sena; https://orcid.org/0000-0001-8268-1986Background: Few studies have explored the impact of ischemic and non-ischemic etiologies of heart failure and other factors associated with heart failure on zinc and copper status. This study examined zinc and copper status in 80 outpatients with ischemic (n ¼ 36) and non-ischemic (n ¼ 44) heart failure and associations with biodemographic, clinical, biochemical, and nutri- tional parameters. Materials: Biomarkers of plasma zinc and copper, copper-zinc ratio, 24-h urinary zinc excretion, ceruloplasmin, and dietary intake of zinc and copper were assessed. Plasma zinc and copper and urinary zinc were measured by inductively coupled plasma mass spectrometry (ICP-MS). Results: Patients with ischemic heart failure showed lower dietary zinc intake and higher dietary copper intake (both p ¼ 0.02). Zinc and copper in plasma, copper-zinc ratio, ceruloplasmin, and 24-h urinary zinc excretion showed no statistical differences between the groups (all p 0.05). An inverse association was found between age (b ¼ 0.001; p ¼ 0.005) and the use of diuretics (b ¼ -0.047; p ¼ 0.013) and plasma zinc. Copper levels in plasma (b = 0.001; p < 0.001), and albumin (b ¼ 0.090; p<0.001) were directly associated with plasma zinc. A positive association was found between ceruloplasmin (b ¼ 0.011; p < 0.001), gamma-glutamyl transferase (b ¼ 0.001; p < 0.001), albumin (b ¼ 0.077; p ¼ 0.001), and high-sensitivity c-reactive protein (b ¼ 0.001; p ¼ 0.024) and plasma copper. Conclusion: Zinc and copper biomarkers in clinically stable patients with heart failure did not seem to be responsive to the differences in zinc and copper intake observed in this study, regard- less of heart failure etiology. The predictors of plasma zinc and copper levels related to oxidative stress and inflammation should be monitored in heart failure clinical practice.TCC Frequência de anemia e consumo alimentar e dietético de ferro em indivíduos com insuficiência cardíaca(Universidade Federal do Rio Grande do Norte, 2021-09-08) Oliveira, Luana Isabelly Carneiro de; Evangelista, Karine Cavalcanti Maurício de Sena; Nunes, Francisca Leide da Silva; https://orcid.org/0000-0003-4170-0559; Freire, Fernanda Lambert de AndradeIntrodução: A insuficiência cardíaca (IC) é uma síndrome complexa, de etiologia miltifatorial. Existem diversas comorbidades associadas, dentre elas a anemia e a deficiência de ferro. A anemia acomete cerca de 33% dos pacientes com IC e a deficiência de ferro cerca de 50%. O tipo mais comum de anemia é a por deficiência de ferro. A ingestão adequada desse micronutriente é muito importante no contexto a IC, tendo em vista que o não tratamento para essas comorbidades está associado à piora e/ou agravo dessa condição clínica. Objetivo: Avaliar a frequência de anemia e o consumo alimentar e dietético de ferro em indivíduos com insuficiência cardíaca. Métodos: O estudo transversal incluiu 124 pacientes adultos e idosos, de ambos os sexos, com diagnóstico clínico de IC, distribuídos por sexo feminino (N=42) e masculino (N=82). A anemia foi diagnosticada com os valores de corte estabelecidos pela WHO (2020) e o consumo alimentar foi realizado por meio de recordatórios 24h e os dados foram analisados no software Virtual Nutri Plus 2.0®. Foi utilizado o Teste “T”-Student e o teste U-Mann-Whitney, quando apropriado, para prevalência de inadequação do ferro foi utilizado distribuição ajustada. Resultados: A idade média dos pacientes foi de 56 (14) anos, em sua maioria do sexo masculino (66%). Cerca de 45% da população apresentou anemia e foi observado também uma frequência mais elevada no sexo feminino (47,4%). A estimativa da prevalência de inadequação se mostrou superior no grupo feminino em idade fértil com anemia, representando cerca de 82%. Em relação aos alimentos fontes de ferro, os mais consumidos foram: coentro, feijão carioca, ovo de galinha e carne vermelha. Conclusão: Os pacientes com IC apresentaram alta frequência de anemia e elevada prevalência de inadequação do consumo de ferro em ambos os sexos, ressaltando a necessidade de intervenções nutricionais como parte do tratamento não farmacológico para essa doença.Artigo Lack of association between inadequate micronutrient intake and prognosis in outpatients with heart failure(Nutrients, 2022) Lima, Severina Carla Vieira Cunha; Torres, Núbia Rafaella Soares Moreira; Freire, Fernanda Lambert de Andrade; Komatsu, Raquel Costa Silva Dantas; Silva, Eduardo Paixão da; Queiroz, Salomão Israel Monteiro Lourenço; Lira, Niethia Regina Dantas de; Diniz, Rosiane Viana Zuza; Pedrosa, Lucia Fatima Campos; Lopes, Márcia Marília Gomes Dantas; Evangelista, Karine Cavalcanti Maurício Sena; https://orcid.org/0000-0001-8268-1986Inadequate nutrient intake can lead to worse outcomes in patients with heart failure (HF). This prospective cohort study aimed to assess the prevalence of inadequate micronutrient intake and their association with prognosis in 121 adult and elderly outpatients with HF. Habitual micronutrient intake was evaluated using 24-h dietary recalls (minimum 2 and maximum 6). Participants were grouped into moderate (n = 67) and high (n = 54) micronutrient deficiency groups, according to the individual assessment of each micronutrient intake. Patients’ sociodemographic, clinical, and anthropometric data and clinical outcomes (hospitalization and mortality) within 24 months were collected. Overall and event-free survival rates were calculated using Kaplan–Meier estimates, and curves were compared using the log-rank test. The death risk rate (hazard ratio (HR)) was calculated using Cox’s univariate model. The rate of inadequate intake was 100% for vitamins B1 and D and above 80% for vitamins B2, B9, and E, calcium, magnesium, and copper. No differences in overall survival and event-free survival were observed between groups of HF outpatients with moderate and high micronutrient deficiencies (HR = 0.94 (CI = 0.36–2.48), p = 0.91, and HR = 1.63 (CI = 0.68–3.92), p = 0.26, respectively), as well as when the inadequacy of each micronutrient intake was evaluated alone (all p > 0.05). In conclusion, a high prevalence of inadequate micronutrient intake was observed in outpatients with HF. Inadequate micronutrient intake was not associated with hospitalization and mortality in this group of patients.Artigo Lack of association between inadequate micronutrient Intake and prognosis in outpatients with heart failure(Nutrients, 2022) Lopes, Márcia Marília Gomes Dantas; Torres, Núbia Rafaella Soares Moreira; Freire, Fernanda Lambert de Andrade; Komatsu, Raquel Costa Silva Dantas; Silva, Eduardo Paixão da; Queiroz, Salomão Israel Monteiro Lourenço; Lira, Niethia Regina Dantas de; Diniz, Rosiane Viana Zuza; Lima, Severina Carla Vieira Cunha; Pedrosa, Lucia Fatima Campos; Evangelista, Karine Cavalcanti Maurício Sena; https://orcid.org/0000-0002-0011-576XInadequate nutrient intake can lead to worse outcomes in patients with heart failure (HF). This prospective cohort study aimed to assess the prevalence of inadequate micronutrient intake and their association with prognosis in 121 adult and elderly outpatients with HF. Habitual micronutrient intake was evaluated using 24-h dietary recalls (minimum 2 and maximum 6). Participants were grouped into moderate (n = 67) and high (n = 54) micronutrient deficiency groups, according to the individual assessment of each micronutrient intake. Patients’ sociodemographic, clinical, and anthropometric data and clinical outcomes (hospitalization and mortality) within 24 months were collected. Overall and event-free survival rates were calculated using Kaplan–Meier estimates, and curves were compared using the log-rank test. The death risk rate (hazard ratio (HR)) was calculated using Cox’s univariate model. The rate of inadequate intake was 100% for vitamins B1 and D and above 80% for vitamins B2, B9, and E, calcium, magnesium, and copper. No differences in overall survival and event-free survival were observed between groups of HF outpatients with moderate and high micronutrient deficiencies (HR = 0.94 (CI = 0.36–2.48), p = 0.91, and HR = 1.63 (CI = 0.68–3.92), p = 0.26, respectively), as well as when the inadequacy of each micronutrient intake was evaluated alone (all p > 0.05). In conclusion, a high prevalence of inadequate micronutrient intake was observed in outpatients with HF. Inadequate micronutrient intake was not associated with hospitalization and mortality in this group of patients.Artigo Vitamin D status and predictors of 25-hydroxyvitamin D levels in patients with heart failure living in a sunny region(Nutrición Hospitalaria, 2021) Evangelista, Karine Cavalcanti Maurício de Sena; Komatsu, Raquel Costa Silva Dantas; Freire, Fernanda Lambert de Andrade; Lira, Niethia Regina Dantas de; Diniz, Rosiane Viana Zuza; Lima, Severina Carla Vieira Cunha; Pedrosa, Lucia Fatima CamposAims: hypovitaminosis D has frequently been identified in patients with heart failure (HF). However, few studies have been conducted in regions with high solar incidence. Therefore, this study aimed to evaluate vitamin D status and predictors of 25-hydroxyvitamin D (25(OH)D) levels in patients with HF living in a sunny region (5 °- 6 °S). Methods: this cross-sectional study enrolled 70 patients with HF. Biodemographic, clinical, biochemical, dietary, and sun exposure data were collected, and 25(OH)D levels were measured. Results: the mean 25(OH)D level was 40.1 (12.4) ng/mL, and 24.3 % (95 % CI: 14.2-33.8) of patients with HF had hypovitaminosis D (25(OH) D < 30 ng/mL). Female patients (p = 0.001), those with ischemic etiology (p = 0.03) and those with high parathyroid hormone levels (> 67 pg/ mL) (p = 0.034) were more likely to present hypovitaminosis D. Higher 25(OH)D levels were observed in men than in women (β = 7.78, p = 0.005) and in patients with HF in New York Heart Association (NHYA) functional class I when compared to those in class III/IV (β = 8.23, p = 0.032). Conclusions: the majority of patients with HF had sufficient 25(OH)D levels. Sex and functional classification were identified as independent predictors of 25(OH)D levels. These results highlight the need for increased monitoring of vitamin D status among female patients with heart failure and those with more severe symptomsArtigo Vitamin D status and predictors of 25-hydroxyvitamin D levels in patients with heart failure living in a sunny region(Nutricion Hospitalaria, 2021) Lima, Severina Carla Vieira Cunha; Komatsu, Raquel Costa Silva Dantas; Freire, Fernanda Lambert de Andrade; Lira, Niethia Regina Dantas de; Diniz, Rosiane Viana Zuza; Pedrosa, Lucia Fatima Campos; Evangelista, Karine Cavalcanti Maurício Sena; https://orcid.org/0000-0001-8268-1986Aims: hypovitaminosis D has frequently been identified in patients with heart failure (HF). However, few studies have been conducted in regions with high solar incidence. Therefore, this study aimed to evaluate vitamin D status and predictors of 25-hydroxyvitamin D (25(OH)D) levels in patients with HF living in a sunny region (5 °- 6 °S). Methods: this cross-sectional study enrolled 70 patients with HF. Biodemographic, clinical, biochemical, dietary, and sun exposure data were collected, and 25(OH)D levels were measured. Results: the mean 25(OH)D level was 40.1 (12.4) ng/mL, and 24.3 % (95 % CI: 14.2-33.8) of patients with HF had hypovitaminosis D (25(OH) D < 30 ng/mL). Female patients (p = 0.001), those with ischemic etiology (p = 0.03) and those with high parathyroid hormone levels (> 67 pg/mL) (p = 0.034) were more likely to present hypovitaminosis D. Higher 25(OH)D levels were observed in men than in women (β = 7.78, p = 0.005) and in patients with HF in New York Heart Association (NHYA) functional class I when compared to those in class III/IV (β = 8.23, p = 0.032). Conclusions: the majority of patients with HF had sufficient 25(OH)D levels. Sex and functional classification were identified as independent predictors of 25(OH)D levels. These results highlight the need for increased monitoring of vitamin D status among female patients with heart failure and those with more severe symptoms.TCC Zinco na urina e o uso de medicamentos anti-hipertensivos em pacientes com insuficiência cardíaca(Universidade Federal do Rio Grande do Norte, 2021-04-13) Silva, Ana Beatriz; Sena-Evangelista, Karine Cavalcanti Maurício; Fernanda Lambert de Andrade Freire; Sena-Evangelista, Karine Cavalcanti Maurício; Freire, Fernanda Lambert de Andrade; Lopes, Márcia Marília Gomes DantasIntrodução: A utilização de medicamentos anti-hipertensivos para tratamento da insuficiência cardíaca (IC) pode afetar o metabolismo do zinco e levar à deficiência desse elemento. Objetivo: Avaliar a excreção urinária de zinco e sua relação com o uso de medicamentos anti-hipertensivos em pacientes com IC. Método: O estudo incluiu 54 pacientes adultos e idosos, de ambos os sexos, com diagnóstico de IC. Foram coletados dados sociobiodemográficos, clínicos e nutricionais. O zinco na urina foi determinado pelo método de espectrometria de massa com plasma indutivamente acoplado (ICP-MS). A ingestão dietética de zinco foi avaliada por recordatórios de 24h, os dados foram analisados no software Virtual Nutri Plus 2.0® e comparados com os valores de recomendação da EAR. Para verificar a distribuição dos dados foi utilizado o teste de Kolmogorov-Smirnov e para associação das variáveis entre os grupos foram utilizados os testes Kruskall Wallis, Qui-quadrado ou teste de Fisher, quando apropriado. Resultados: Os pacientes foram divididos em três grupos de acordo com o número de medicamentos anti-hipertensivos utilizados, sendo eles: dois (n=12), três (n=24) e quatro ou mais (n=18). Foi observada maior frequência de pessoas do sexo masculino (70%), em classe funcional I/II (93%) e fração de ejeção do ventrículo esquerdo (FEVE) reduzida (56%). Além disso, observou-se maior frequência de IC não isquêmica (57%) e presença de hipertensão arterial (67%). Os diuréticos foram utilizados por 87% da amostra. Foi encontrada uma mediana de ingestão de zinco de 7,06mg/dia (4,85 - 10,23) e valores de zinco urinário com mediana de 366,83 µg/24h (229,38 – 542,38), sem diferença estatística entre os grupos (todos p>0,05). Observou-se que 80% da amostra total apresentou zincúria abaixo de 600 µg/24h. Conclusão: Os pacientes apresentaram ingestão de zinco na dieta menor que o recomendado. A zincúria foi um achado pouco frequente em nossos pacientes, independentemente do número de medicamentos anti-hipertensivos utilizados.