Navegando por Autor "Fregonezi, Guilherme"
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Artigo Effects of air stacking maneuver on cough peak flow and chest wall compartmental volumes of subjects with amyotrophic lateral sclerosis(Elsevier, 2017) Dourado Junior, Mário Emílio Teixeira; Sarmento, Antonio; Resqueti, Vanessa Resqueti; Saturnino, Lailane; Aliverti, Andrea; Fregonezi, Guilherme; Andrade, Armele Dornelas de; https://orcid.org/0000-0002-9462-2294Objectives To assess the acute effects of air stacking on cough peak flow (CPF) and chest wall compartmental volumes of persons with amyotrophic lateral sclerosis (ALS) versus healthy subjects positioned at 45° body inclination. Design Cross-sectional study with a matched-pair design. Setting University hospital. Participants Persons (N=24) with ALS (n=12) and age-matched healthy subjects (n=12). Main Outcomes Measures CPF, chest wall compartmental inspiratory capacity, chest wall vital capacity, chest wall tidal volume and operational volumes, breathing pattern, and percentage of contribution of the compartments to the inspired volume were measured by optoelectronic plethysmography. Results Compared with healthy subjects, significantly lower CPF (P=.007), chest wall compartmental inspiratory capacity (P<.001), chest wall vital capacity (P<.001), and chest wall tidal volume (P<.001) were found in subjects with ALS. Immediately after air stacking, CPF (P<.001) and chest wall compartmental inspiratory capacity (P<.001) significantly increased in both groups, with values returning to basal only in healthy subjects. After air stacking, the abdominal compartment (P=.004) was determined to be responsible for the inspired volume in subjects with ALS. Significantly higher chest wall vital capacity (P=.05) was observed in subjects with ALS 5 minutes after air stacking, with the rib cage compartment (P=.049) being responsible for volume change. No differences were found in chest wall vital capacity and compartmental volumes of healthy subjects. Chest wall tidal volume (P<.001) significantly increased during the protocol in the healthy subjects, mainly because of end-inspiratory (P<.001) and abdominal volumes (P=.008). No significant differences were observed in percentage of contribution of the compartments to the inspired volume and end-expiratory volume of both groups. No significant differences were found in chest wall tidal volume, operational volume, and breathing pattern in persons with ALS. Conclusions Air stacking is effective in increasing CPF, chest wall compartmental inspiratory capacity, and chest wall vital capacity of persons with ALS with no hyperinflation. Differences in compartmental volume contributions are probably because of lung and chest wall physiological changes.Artigo Effects of respiratory muscle training on respiratory muscle strength and heart rate variability in myotonic dystrophy patients type 1(Journal of Respiratory and CardioVascular Physical Therapy, 2012) Dourado Junior, Mário Emílio Teixeira; Araújo, Thayse Lucena; Resqueti, Vanessa Regiane; Lima, Illia Nadinne Dantas Florentino; Fregonezi, Guilherme; https://orcid.org/0000-0002-9462-2294Introduction: Myotonic dystrophy (MD) is a multisystemic neuromuscular disease responsible for causing progressive respiratory muscle weakness. Respiratory muscle training (MRT) has been shown to be effective in several diseases; however, its effects on respiratory and cardiac functions in MD are still inconsistent. Objective: Assess the effects of MRT on respiratory muscle strength and heart rate variability in patients with type 1 myotonic dystrophy. Methods: The sample was composed of 6 individuals of both sexes. The following was assessed: respiratory muscle strength, before and after training (sessions 1-4) and heart rate variability before and after sessions 2 and 3. The group submitted to MRT used the Threshold IMT device, adapted for inspiratory and expiratory training, three times a week, once at an outpatient facility and twice at home. Results were expressed as median and interquartile ranges for pulmonary function variables, and the Friedman and Wilcoxon tests were applied to compare heart rate variability. Results: respiratory muscle strength significantly improved expiratory and inspiratory muscles (33% and 20%, respectively), considering training sessions 1-4. With respect to variability, there was a 102% increase in sympathetic activity, reflected by low frequency and 194% increase in vagal tonus, represented by high frequency. Conclusions: Preliminary study results demonstrate that a partial home-based respiratory muscle-training program is feasible, in addition to improving strength and heart rate variability in patients with MD.Artigo Força muscular respiratória e perfil postural e nutricional em crianças com doenças neuromusculares(Fisioterapia em Movimento, 2012) Dourado Junior, Mário Emílio Teixeira; Pontes, Jaqueline Fernandes; Ferreira, Gardenia Maria Holanda; Fregonezi, Guilherme; Evangelista, Karine Cavalcanti Maurício de Sena; https://orcid.org/0000-0002-9462-2294As doenças neuromusculares infantis são crônicas, degenerativas e determinam alterações funcionais, musculares e nutricionais. OBJETIVOS: Avaliar sistematicamente a força muscular respiratória e o perfil postural e nutricional de crianças com doenças neuromusculares em seguimento multidisciplinar institucional. MATERIAIS E MÉTODOS: Foram estudados pacientes com diferentes doenças neuromusculares por meio da verificação da força muscular respiratória, da avaliação nutricional de massa muscular, do índice de massa corpórea e da porcentagem (%) de gordura corporal, além de avaliação postural e dos padrões de movimento. RESULTADOS: Foram avaliados 41 sujeitos. As crianças do sexo masculino predominaram na população em estudo, sendo 82,9% dela (n = 34), e os outros 17,1% (n = 7) eram do sexo feminino. A média de idade encontrada foi de 9,65 ± 3,11 anos. O principal diagnóstico encontrado foi Distrofia Muscular de Duchenne, 43,9% (n = 18), seguido de Atrofia Muscular Espinhal, 9,75% (n = 4), Distrofia Congênita, 7,31% (n = 3), Distrofia Muscular de Cinturas, Polineuropatia e Miopatia Congênita, todos com 4,9% (n = 2), além de Distrofia Muscular Progressiva, Miastenia Grávis, Charcoot Marie Toot, Emery Dreifuss, encontrados em 2,43% (n = 1). Foi verificada uma diminuição da força muscular respiratória (PImáx = 81 ± 24,3 cmH2O, 91% predito e PEmáx = 70 ± 29,6 cmH2O, 72% predito), mais evidente nos músculos expiratórios. A Hiperlordose lombar foi encontrada em 26 pacientes (64%) e 9 pacientes (22%) já haviam perdido a capacidade de deambular. Em relação ao perfil nutricional, 90% dos pacientes (n = 30) mostraram uma alta incidência de perda de reserva muscular e 52% deles (n = 13) apresentaram a porcentagem de gordura corporal abaixo do aceitável. CONCLUSÃO: A avaliação multidisciplinar das doenças neuromusculares pediátricas podem auxiliar no estabelecimento de tratamento precoce da Fisioterapia para melhorar a qualidade de vida dos pacientes e cuidadores.Artigo Monitoring respiratory muscle strength assists in early diagnosis of respiratory dysfunction as opposed to the isolated use of pulmonary function evaluation in amyotrophic lateral sclerosis(Arquivos de Neuro-Psiquiatria, 2013-03) Dourado Junior, Mário Emílio Teixeira; Fregonezi, Guilherme; Araújo, Paloma Russelly Saldanha; Macêdo, Tathiana Lindemberg Ferreira; Resqueti, Vanessa Regiane; Andrade, Armele de Fátima Dornelas de; https://orcid.org/0000-0002-9462-2294Objetivo: Estudar a relação entre a força dos músculos respiratórios e a capacidade vital forçada (CVF) em pacientes com esclerose lateral amiotrófica (ELA) e sujeitos saudáveis. Métodos: Avaliamos a função pulmonar e a força dos músculos respiratórios [pressão inspiratória (PImax), pressão expiratória (PEmax) e pressão inspiratória nasal de sniff (SNIP)] utilizando pontos de corte estabelecidos na literatura para diagnóstico de fraqueza muscular respiratória. Resultados: Foram estudados 28 pacientes com ELA e 28 sujeitos saudáveis. Encontramos sensibilidade e especificidade para PImax, PEmax e SNIP de 75/58%, 81/67% e 75/67%. A curva ROC (Receiver Operating Characteristic) indicou que as variáveis PImax, PEmax e SNIP podem identificar diferenças na força dos músculos respiratórios em pacientes com ELA versus sujeitos saudáveis em 0,89, 0,9 e 0,82 respectivamente. Foi encontrada uma correlação positiva entre CVF (%) e SNIP, PImax e PEmax. Conclusão: Em pacientes com ELA, o monitoramento da força muscular respiratória auxilia no diagnóstico precoce da disfunção em detrimento do uso da CVF isolada.Artigo Multiparametric analysis of sniff nasal inspiratory pressure test in middle stage amyotrophic lateral sclerosis(Frontiers in Neurology, 2018-05-02) Dourado Junior, Mário Emílio Teixeira; Sarmento, Antonio; Aliverti, Andrea; Marques, Layana; Pennati, Francesca; Fregonezi, Guilherme; Fregonezi, Vanessa Regiane Resqueti; https://orcid.org/0000-0002-9462-2294The relaxation rates and contractile properties of inspiratory muscles are altered with inspiratory muscle weakness and fatigue. This fact plays an important role in neuromuscular disorders patients and had never been extensively studied in amyotrophic lateral sclerosis (ALS). In this cross-sectional study, these parameters were investigated non-invasively through nasal inspiratory sniff pressure test (SNIP) in 39 middle stage spinal onset ALS subjects and compared with 39 healthy controls. ALS patients were also divided into three subgroups according to a decline in their percentage of predicted forced vital capacity (FVC%pred) as well as a decline in the ALS functional rating scale score and its respiratory subscore (R-subscore) in order to determine the best parameter linked to early respiratory muscle weakness. When compared with healthy subjects, middle stage ALS subjects exhibited a significantly lower (p < 0.0001) maximum relaxation rate and maximum rate of pressure development (MRPD), as well as a significantly higher (p < 0.0001) tau (τ), contraction time, and half-relaxation time. The results from receiver operating characteristic curves showed that MRPD (AUC 0.735, p < 0.001) and FVC%pred (AUC 0.749, p = 0.009) were the best discriminator parameters between ALS patients with ≤30 and >30 points in the ALS functional rating scale. In addition, 1/2RT (AUC 0.720, p = 0.01), FVC%pred (AUC 0.700, p = 0.03), τ (AUC 0.824, p < 0.0001), and MRPD (AUC 0.721, p = 0.01) were the parameters more sensitive in detecting a fall of three points in the R-subscore. On the other hand, MRPD (AUC 0.781, p < 0.001), τ (AUC 0.794, p = 0.0001), and percentage of predicted of SNIP (AUC 0.769, p = 0.002) were the parameters able to detect a fall in 30% of the FVC%pred in middle stage ALS patients. The contractile properties and relaxation rates of the diaphragm are altered in middle stage spinal onset ALS when compared with healthy subjects. These parameters are able to discriminate between those middle stage ALS subjects with early decline in inspiratory muscle function and those who not.Artigo Muscle impairment in neuromuscular disease using an expiratory/inspiratory pressure ratio(Respiratory Care, 2015) Dourado Junior, Mário Emílio Teixeira; Fregonezi, Guilherme; Azevedo, Ingrid G; Resqueti, Vanessa R; Andrade, Arme`le D De; Gualdi, Lucien P; Aliverti, Andrea; Parreira, Veronica F; https://orcid.org/0000-0002-9462-2294Neuromuscular diseases (NMDs) lead to different weakness patterns, and most patients with NMDs develop respiratory failure. Inspiratory and expiratory muscle strength can be measured by maximum static inspiratory pressure (PImax) and maximum static expiratory pressure (PEmax), and the relationship between them has not been well described in healthy subjects and subjects with NMDs. Our aim was to assess expiratory/inspiratory muscle strength in NMDs and healthy subjects and calculate PEmax/PImax ratio for these groups. METHODS: Seventy (35 males) subjects with NMDs (amyotrophic lateral sclerosis, myasthenia gravis, and myotonic dystrophy), and 93 (47 males) healthy individuals 20 – 80 y of age were evaluated for anthropometry, pulmonary function, PImax, and PEmax, respectively. RESULTS: Healthy individuals showed greater values for PImax and PEmax when compared with subjects with NMDs. PEmax/PImax ratio for healthy subjects was 1.31 0.26, and PEmax%/PImax% was 1.04 0.05; for subjects with NMDs, PEmax/PImax ratio was 1.45 0.65, and PEmax%/PImax% ratio was 1.42 0.67. We found that PEmax%/PImax% for myotonic dystrophy was 0.93 0.24, for myasthenia gravis 1.94 0.6, and for amyotrophic lateral sclerosis 1.33 0.62 when we analyzed them separately. All healthy individuals showed higher PEmax compared with PImax. For subjects with NMDs, the impairment of PEmax and PImax is different among the 3 pathologies studied (P < .001). CONCLUSIONS: Healthy individuals and subjects with NMDs showed higher PEmax in comparison to PImax regarding the PEmax/PImax ratio. Based on the ratio, it is possible to state that NMDs show different patterns of respiratory muscle strength loss. PEmax/PImax ratio is a useful parameter to assess the impairment of respiratory muscles in a patient and to customize rehabilitation and treatment.Artigo Thoracoabdominal asynchrony and paradoxical motion in middle stage amyotrophic lateral sclerosis(Elsevier, 2019) Dourado Junior, Mário Emílio Teixeira; Sarmento, Antonio; Fregonezi, Guilherme; Aliverti, Andrea; Andrade, Armele Dornelas de; Parreira, Verônica Franco; Resqueti, Vanessa; https://orcid.org/0000-0002-9462-2294Aim: To assess thoracoabdominal asynchrony (TAA) and the presence of paradoxical motion in middle stage amyotrophic lateral sclerosis (ALS) and its relationships with chest wall tidal volume (VT,CW), breathing pattern and cough peak flow (CPF). Methods: Phase angle (θ) between upper (RCp) and lower ribcage (RCa) and abdomen (AB), as well as percentage of inspiratory time for the lower ribcage (IPRCa) and abdomen (IPAB) moving in opposite directions were quantified using optoelectronic plethysmography in 12 ALS patients during quiet breathing and coughing. Paradoxical motion of the compartments was based on threshold values of θ and IP, obtained in twelve age and sex matched healthy persons. Results: During quiet breathing, significantly higher RCa and AB θ (p < .05), IPRCa (p = 0.001) and IPAB (p < 0.05) were observed in ALS patients as compared to controls. In ALS patients, correlations between RCa and AB θ with forced vital capacity (FVC) (r=–0.773, p < 0.01), vital capacity (r=–0.663, p < 0.05) and inspiratory capacity (IC) (r=–0.754, p < 0.01), as well as between RCp and RCa θ with FVC (r=–0.608, p < 0.05) and CPF (r=–0.601, p < 0.05) were found. During coughing, correlations between RCp and AB θ with CPF (r=–0.590, p < 0.05), IC (r=–0.748, p < 0.01) and VT,CW (r=–0.608, p < 0.05), as well as between RCa and AB θ with CPF (r=–0.670, p < 0.05), IC (r=–0.713, p < 0.05) and peak expiratory flow (r=–0.727, p < 0.05) were also observed in ALS patients. ALS patients with paradoxical motion presented lower vital capacity and FVC%pred (p < 0.05) compared to those without paradoxical motion. Conclusions: Middle stage ALS patients exhibit TAA and paradoxical motion during quiet spontaneous breathing and coughing. In addition, diaphragmatic weakness (i.e. decrease in excursion of the RCa and AB compartments) was observed earlier in the lower ribcage rather than the abdominal compartment in this population.