Navegando por Autor "Evangelista, Karine Cavalcanti Maurício Sena"
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Artigo Are phosphatidylcholine and lysophosphatidylcholine body levels potentially reliable biomarkers in obesity?: a review of human studies(Molecular Nutrition & Food Research, 2023-01) Reis, Bruna Zavarize; Bellot, Paula Emília Nunes Ribeiro; Moia, Melissa Nunes; Pedrosa, Lucia Fatima Campos; Tasic, Ljubica; Barbosa, Fernando; Evangelista, Karine Cavalcanti Maurício SenaPhosphatidylcholines (PCs) are the major components of biological membranes in animals and are a class of phospholipids that incorporate choline as a headgroup. Lysophosphatidylcholines (LPCs) are a class of lipid biomolecules derived from the cleavage of PCs, and are the main components of oxidized low-density lipoproteins (oxLDLs) that are involved in the pathogenesis of atherosclerosis. Since obesity is associated with a state of chronic low-grade inflammation, one can anticipate that the lipidomic profile changes in this context and both PCs and LPCs are gaining attention as hypothetically reliable biomarkers of obesity. Thus, a literature search is performed on PubMed, Latin American and Caribbean Health Science Literature (LILACS), and Excerpta Medica DataBASE (Embase) to obtain the findings of population studies to clarify this hypothesis. The search strategy resulted in a total of 2403 reports and 21 studies were included according to the eligibility criteria. Controversial data on the associations of PCs and LPCs with body mass index (BMI) and body fat parameters have been identified. There is an inverse relationship between BMI and most species of PCs, and a majority of studies exhibited negative associations between BMI and LPCs. Other findings regarding the differences between PCs and LPCs in obesity are presented, and the associated uncertainties are discussed in detailArtigo Associations between components of metabolic syndrome and demographic, nutritional, and lifestyle factors(Wiley, 2024) Lima, Severina Carla Vieira Cunha; Aquino, Séphora Louyse Silva; Cunha, Aline Tuane Oliveira da; Peixoto, Talita do Nascimento; Lima, Layne Christina Benedito de Assis; Evangelista, Karine Cavalcanti Maurício Sena; Lima, Josivan Gomes; Pedrosa, Lucia Fátima Campos; https://orcid.org/0000-0001-8268-1986Objectives. To evaluate the associations between individuals with and without changes in components of metabolic syndrome (MetS) and demographic, nutritional, and lifestyle factors. Methods. A cross-sectional study was conducted with 224 individuals followed-up at a public hospital in Northeast Brazil. We used National Cholesterol Education Program-Adult Treatment Panel III (NCEP) criteria to diagnose MetS. We assessed components of MetS as dependent variables, while sex, age, food consumption, smoking, alcohol intake, physical activity, anthropometric parameters, and sleep hours were independent variables. Results. Comparing individuals with and without changes in components of MetS, the logistic regression models revealed that female sex was predictive of increased waist circumference and low HDL-c levels while advanced age was predictive of increased blood pressure and blood glucose levels. BMI emerged as a predictor for waist circumference and a protective factor for triglyceride levels. In addition, potassium intake, physical activity, and sleep duration were protective against decreased HDL-c, elevated triglyceride, and elevated blood pressure levels, respectively. Conclusion. This study demonstrated that sex, age, BMI, dietary potassium intake, physical activity, and hours of sleep are factors to be targeted in public health actions for prevention and treatment of MetS.Artigo Biomarcadores de peroxidação lipídica na aterosclerose(Revista de Nutrição, 2008-12) Evangelista, Karine Cavalcanti Maurício Sena; Abdalla, Dulcinéia Saes ParraA aterosclerose é caracterizada por uma resposta inflamatória crônica da parede arterial, iniciada por uma lesão do endotélio, cuja etiologia está relacionada à modificação oxidativa da lipoproteína de baixa densidade. O objetivo deste trabalho é apresentar os principais metabólitos envolvidos nos processos bioquímicos de peroxidação lipídica, discutindo as vantagens e desvantagens dos métodos empregados para a mensuração dos biomarcadores de peroxidação lipídica relacionados com a aterosclerose. A avaliação da oxidação das lipoproteínas pode ser realizada pela determinação dos produtos gerados durante a peroxidação lipídica, como os isoprostanos, hidroperóxidos lipídicos, aldeídos, fosfolípides oxidados e os produtos da oxidação do colesterol. A suscetibilidade das partículas de lipoproteína de baixa densidade à oxidação pode ser avaliada in vitro, após a indução da peroxidação lipídica por azoiniciadores radicalares lipossolúveis, hidrossolúveis, ou mais comumente, pelos íons cobre. Por outro lado, as modificações da lipoproteína de baixa densidade, pela ação das lipoxigenases e peroxidases, ou oxidação não-enzimática, resultam no aumento da carga negativa destas partículas e podem contribuir para a geração in vivo de uma subfração de lipoproteína de baixa densidade minimamente oxidada, denominada lipoproteína de baixa densidade eletronegativa (lipoproteína de baixa densidade). A determinação das concentrações desta partícula pode ser realizada em plasma por cromatografia líquida ou por imunoensaios..Diversos métodos podem ser utilizados para a avaliação dos biomarcadores de peroxidação lipídica in vivo e in vitro, porém, a definição do marcador mais adequado, depende de uma avaliação criteriosa das vantagens, desvantagens e particularidades de cada análise, levandose em consideração os objetivos do estudo que será conduzidoArtigo Cardiometabolic risk factors and hypovitaminosis D in adolescents with overweight from a sunny region in northeast Brazil: a cross-sectional study(Nutricion hospitalaria, 2022) Lima, Severina Carla Vieira Cunha; Souza, Angélica Luiza de Sales; Araújo, Eduarda Pontes dos Santos; Souza, Thatyane Oliveira; Pimentel, Jéssica Bastos; Ferreira, Adriana Leão de Miranda; Silva, David Franciole de Oliveira; Evangelista, Karine Cavalcanti Maurício Sena; Arrais, Ricardo Fernando; Rezende, Adriana Augusto de; https://orcid.org/0000-0001-8268-1986Background: obesity can influence vitamin D levels, which in turn might be associated with cardiometabolic risk factors. Objectives: this study assessed the association between 25-hydroxyvitamin D [25(OH)D] levels and cardiometabolic risk factors in adolescents with overweight living in a region of northeastern Brazil. Material and methods: a cross-sectional study was carried out by non-probabilistic sampling in adolescents diagnosed with overweight or obesity. The subjects were divided according to their 25(OH)D status into two groups: sufficient vitamin D and hypovitaminosis D. Biodemographic, lifestyle, cardiometabolic, and biochemical factors were evaluated. A logistic regression model was applied to determine the predictors of hypovitaminosis D. Results: we found a high frequency of hypovitaminosis D (45.6 %) in adolescents. Weekly sun exposure was negatively associated with hypovitaminosis D (OR = 0.96; 95 % CI: 0.92-0.99), while significant positive associations were observed between hypovitaminosis D and blood pressure above the 95th percentile (OR = 4.00; 95 % CI: 1.19-13.37), body weight (OR = 1.04; 95 % CI: 1.01-1.07), and fasting insulin (OR = 1.13; 95 % CI: 1.05-1.22). Conclusion: hypovitaminosis D showed a high prevalence in adolescents with overweight living in a sunny region of northeastern Brazil, and cardiometabolic risk factors such as systemic arterial hypertension, high body weight, and hyperinsulinemia are predictors of hypovitaminosis D.TCC Consumo alimentar e dietético de magnésio em indivíduos com insuficiência cardíaca isquêmica e não-isquêmica(Universidade Federal do Rio Grande do Norte, 2024-06-18) Medeiros, Erika Maria Araújo de; Evangelista, Karine Cavalcanti Maurício Sena; Souza Júnior, Adriano Carlos de; http://lattes.cnpq.br/3656687217332458; http://lattes.cnpq.br/2628723272728505; http://lattes.cnpq.br/5316694772396428; Moia, Melissa NunesIntrodução: O magnésio desempenha um papel crucial para a saúde cardiovascular tendo em vista as suas funções, em especial, a de estabilidade da membrana neuromuscular e cardiovascular e manutenção do tônus vasomotor. Em indivíduos com insuficiência cardíaca (IC), a deficiência de magnésio está relacionada com o risco de desnutrição e complicações da saúde cardiovascular. Objetivo: Avaliar o consumo alimentar e dietético de magnésio em indivíduos com IC atendidos ambulatorialmente. Metodologia: Trata-se de um estudo transversal realizado com 106 indivíduos, distribuídos conforme a etiologia da IC isquêmica e não-isquêmica. Foram avaliadas variáveis sociobiodemográficas e clínicas. O consumo alimentar e de magnésio foi obtido por meio de Recordatórios de 24 horas. A análise das dietas foi realizada utilizando o software Virtual Nutri Plus 2.0®, considerando as informações da Tabela Brasileira de Composição de Alimentos (TBCA). Foi utilizado o Multiple Source Method (MSM) para correção da variabilidade intrapessoal. Adicionalmente, foram avaliados os alimentos que mais contribuíram para a ingestão de magnésio e classificados em alimento fonte, boa fonte e excelente fonte. Resultados: Identificamos uma ingestão mediana de magnésio de 183,8 (160,9 - 221,2) µg/dia na amostra total, sem diferença entre os grupos (p=0,571). O consumo de magnésio foi menor que os valores propostos conforme a Estimated Average Requirement (EAR) em quase a totalidade dos participantes. Avaliando os recordatórios alimentares, percebemos que os alimentos excelente-fonte de magnésio, por porção média consumida, foram o feijão, aveia e banana. Conclusão: O consumo alimentar e dietético de magnésio está abaixo do recomendado em quase a totalidade dos participantes, destacando-se que os alimentos que mais contribuíram para o consumo deste micronutriente são aqueles típicos da alimentação brasileira e de fácil acesso. Os resultados apontam para a necessidade de atenção especial à ingestão desse elemento para a prevenção de desfechos clínicos desfavoráveis nessa população.Artigo Consumo de sódio em indivíduos com síndrome metabólica: um estudo baseado no teor de sódio da dieta e alimentos-fonte(Demetra, 2018) Lima, Severina Carla Vieira Cunha; Carvalho, Giovanna Melo de; Soares, Jainara da Silva; Freitas, Erika Paula Silva; Lima, Josivan Gomes; Evangelista, Karine Cavalcanti Maurício Sena; https://orcid.org/0000-0001-8268-1986Objetivo: Avaliar a ingestão energética e identificar o consumo de sódio e suas principais fontes em indivíduos com síndrome metabólica. Metodologia: Estudo tipo transversal realizado com 88 indivíduos com diagnóstico de síndrome metabólica, de ambos os sexos, adultos e idosos atendidos no Ambulatório de Endocrinologia do Hospital Universitário Onofre Lopes, Natal, RN. O consumo de energia, sódio e respectivos alimentos-fonte foram avaliados por meio de dois recordatórios de 24 horas, cuja análise foi realizada no Virtual Nutri Plus®. Resultados e discussão:A população estudada era predominantemente feminina (72,7%), com média de idade de 49,0 (11,3) anos. As comorbidades mais frequentes foram dislipidemia (92,0%) e hipertensão arterial (76,1%). Observou-se ingestão energética média de 1.664,4 (630,8) kcal/d e consumo médio de sódio de 2.792,8 (866,2) mg/d, registrando-se 82,2% dos indivíduos com ingestão acima do recomendado. Diferenças estatísticas significativas foram encontradas para ingestão energética entre os sexos (p<0,001), mas não para consumo de sódio (p=0,107). A utilização do sal de adição foi bastante expressiva na análise do consumo alimentar dessa população (310 repetições, correspondendo a uma média de 635,5mg de sódio). Alimentos industrializados foram os que apresentaram maior quantidade de sódio entre os alimentos consumidos, apesar de registrarmos poucos indivíduos fazendo uso desses produtos. Conclusão: A ingestão inadequada de sódio foi registrada em um percentual expressivo da população, podendo ter impacto negativo na saúde desses indivíduos, especialmente aqueles que convivem com hipertensão, evidenciando a necessidade de uma ação de educação nutricional mais ampla direcionada especificamente para essa população.Palavras-chave: Síndrome metabólica. Dieta hipossódica. Hipertensão. Consumo de alimentos.Artigo Development and content validity of an instrument for assessing the motivation for weight loss in adolescents with overweight and obesity(Plos one, 2020) Lima, Severina Carla Vieira Cunha; Silva, David Franciole Oliveira; Souza, Angélica Luiza de Sales; Pimentel, Jéssica Bastos; Souza, Thatyane Oliveira; Araújo, Eduarda Pontes dos Santos; Evangelista, Karine Cavalcanti Maurício Sena; Arrais, Ricardo Fernando; https://orcid.org/0000-0001-8268-1986Objective: To develop and validate the content of an instrument for assessing the motivation for weight loss in adolescents with overweight and obesity. Methods: The development and validation of the instrument were conducted in five stages, for which two systematic reviews were conducted. The first one, for the identification of questionnaires assessing the motivation for weight loss, included six studies and contributed to the selection of the domains for the instrument. The second one, conducted to identify the motivations for weight loss in adolescents with overweight and/or obesity, included six studies and contributed to the selection of 17 motivations included in the initial version of the instrument. The motivations most commonly identified were: having better health, improving my appearance, improving my self-esteem and avoiding bullying. The content validity was confirmed by a committee of 12 experts from the areas of nutrition, endocrinology, psychology, and physical education. Based on these evaluations, the content validity index was calculated. Only the items with a content validity index >0.80 for practical relevance were held in the instrument. Results: Five of the 17 motivations included in the initial version of the instrument were excluded because they had content validity index <0.80 for practical relevance. Of the 12 items held in the instrument, five were revised by experts in order to standardize wording and make the language more appropriate for adolescents. Experts categorized the items into the health, personal satisfaction, appearance and social domains. Conclusions: This is the first instrument assessing the motivation for weight loss in adolescents with overweight and obesity in Brazil. The content validity evaluation by the panel of experts provided more practical relevance, as well as contributed to a better presentation of the items. Further psychometric testing is needed to determine reliability and construct validity of the instrument.Artigo Development of immunoassays for anti-electronegative LDL autoantibodies and immune complexes(Clinica Chimica Acta, 2012-01) Evangelista, Karine Cavalcanti Maurício Sena; Faulin, Tanize do Espirito Santo; Pacheco, Débora Bezerra; Augusto, Elaine Moura; Abdalla, Dulcineia Saes ParraBackground: Electronegative low-density lipoprotein (LDL−) promotes atherosclerosis through inflammatory and immunologic mechanisms that lead to the production of anti-LDL(−) autoantibodies and to the subsequent formation of immune complexes (IC) and macrophage foam cells. We described the development and validation of an ELISA for the quantification of free anti-LDL(−) autoantibodies and an ELISA for the quantification of IC consisting of LDL(−)-bound IgG in human plasma. Methods: LDL(−) purified from human plasma, and anti-LDL(−) monoclonal antibody Fab fragments were adsorbed onto ELISA plates to capture anti-LDL(−) autoantibodies and IC-LDL(−), respectively. The performance characteristics of both ELISAs, including the limits of detection and quantification, accuracy and interand intra-assay precision were evaluated. Linearity, interference and stability tests were also performed. Results: The calibration range of the anti-LDL(−) assay was 0.004–0.125 mU/l and plasma demonstrated a dilutional linearity when diluted 1:100, 1:200, 1:400 and 1:800. The calibration range of the IC-LDL(−) assay was 0.06–4 U/l, and plasma demonstrated a dilutional linearity when diluted 1:12.5, 1:25, 1:50 and 1:100. Both ELISAs showed intra- and inter-assay precision and recovery within the required limits for immunoassays. Conclusion: These ELISAs can be used in clinical studies and for the biochemical investigation of atherosclerosis. In addition, they will enable the comprehensive evaluation of the importance of bound or free autoantibodies against LDL(−) in this diseaseArtigo Efeito da suplementação com zinco sobre a zincúria de pacientes com diabetes tipo 1(Arquivos Brasileiros de Endocrinologia & Metabologia, 2003-10) Evangelista, Karine Cavalcanti Maurício Sena; Arrais, Ricardo Fernando; Brito, Tereza Neuma de Souza; Almeida, Maria das Graças; Pedrosa, Lucia de Fatima CamposNeste estudo foi investigado o efeito da suplementação oral de zinco (Zn) em crianças e adolescentes com diabetes (DM), avaliando o controle metabólico da doença e concentrações de Zn na urina. A amostra foi constituída por 20 pacientes com DM tipo 1, os quais foram comparados com um grupo controle (n=17). O controle metabólico foi avaliado pela glicemia de jejum, glicosúria 24h e HbA1c. As concentrações de Zn foram investigadas na urina de 24h antes (T1) e após a suplementação (T2). Após a 1a coleta de dados dos pacientes com DM1 (T1), teve início a suplementação oral com Zn bis-glicina quelato sem sabor, por um período de 4 meses. As doses foram estabelecidas baseadas nas Dietary Reference Intakes. Os resultados evidenciaram um controle metabólico insatisfatório da doença, devido ao aumento da HbA1c de alguns pacientes, após a suplementação. A excreção urinária de Zn foi maior nos pacientes com DM1 e esteve correlacionado positivamente com o tempo de doença e HbA1c. A suplementação com Zn não corrigiu a heterogeneidade na variação circadiana da zincúria nos pacientes estudados, sugerindo que o controle metabólico inadequado no DM predispõe a distúrbios no metabolismo do Zn, independente da fonte, alimentar ou medicamentosaArtigo Efeitos da suplementação com zinco sobre o crescimento, sistema imunológico e diabetes(Revista de Nutrição, 2005-04) Evangelista, Karine Cavalcanti Maurício Sena; Pedrosa, Lucia de Fátima CamposO zinco apresenta funções catalíticas, estruturais e reguladoras, sendo componente de várias enzimas. Os sintomas observados na deficiência deste elemento incluem lesões de pele, anorexia, retardo do crescimento, hipogonadismo e alteração na função imune. O objetivo desta revisão foi apresentar as funções metabólicas e funcionais do zinco, enfatizando as conseqüências da deficiência e os aspectos que justificam os estudos envolvendo a suplementação com zinco e seus efeitos sobre o crescimento, sistema imunológico e diabetes. Considerando que algumas doenças predispõem o organismo à deficiência de zinco, a suplementação, isoladamente ou associada a outros elementos, demonstra benefícios, especialmente no aumento da velocidade de crescimento, funcionamento do sistema imunológico, diminuição das afecções respiratórias e controle das diarréias. A suplementação em pacientes com diabetes está relacionada com as variáveis do controle metabólico e as concentrações plasmáticas e eritrocitárias de zinco. As estratégias de suplementação com zinco, em populações de risco, devem ser implementadas, considerando-se as doses adequadas de ingestãoArtigo Effects of zinc supplementation in patients with type 1 diabetes(Biological Trace Element Research, 2005) Evangelista, Karine Cavalcanti Maurício Sena; Arrais, Ricardo Fernando; Almeida, Maria das Graças; Araújo, Dina Maria de; Santos, Mirza Medeiros dos; Lima, Vanessa Teixeira de; Pedrosa, Lucia de Fátima CamposThe purpose of this study was to identify the effect of oral zinc supplementation in patients with type 1 diabetes (T1DM) on metabolic control and zinc blood concentrations. The sample consisted of 20 patients with T1DM and a control group (n=17). Metabolic control was evaluated by glycemia at fast, 24 h glycosuria, and HbA1c. Zinc concentrations were measured in plasma and erythrocytes. After the first collection of biological material, oral zinc supplementation was initiated and continued for 4 mo in T1MD patients (T1). Daily dosages were established based on Dietary Recommended Intakes (DRIs), considering zinc intake based on data from other studies previously performed with this population. All analyses were repeated after supplementation (T2). Metabolic control was unsatisfactory, with an HbA1c increase at T2. There was no difference in zinc concentrations in plasma and erythrocytes between patients with T1DM and control. Zinc concentrations in plasma were within the normal range in T1MD before and after supplementation and the control. Zinc concentrations in erythrocyte presented lower than normal values for all groups. A zinc increase in erythrocyte after supplementation was observed in T1DM patients, although without statistical significance. More studies are needed to confirm oral zinc supplementation as nutritional management in diabetesArtigo Instruments for evaluation of motivations for weight loss in individuals with overweight and obesity: a systematic review and narrative synthesis(PLoS One, 2019-07) Lyra, Clélia de Oliveira; Silva, David Franciole Oliveira; Evangelista, Karine Cavalcanti Maurício Sena; Pedrosa, Lucia Fátima Campos; Arrais, Ricardo Fernando; Lima, Severina Carla Vieira CunhaThis systematic review aims to identify instruments used to assess motivations for weight loss in individuals with overweight and obesity from different age groups, such as children, adolescents, adults, and older adults. The virtual search was carried out using the PubMed, Scopus, LILACS, and ADOLEC databases, and by manual search. The following descriptors were used: questionnaire, scale, instrument, evaluation, motivation, motive, reason, “lose weight,” “losing weight,” “weight loss,” and slimming. Methodological quality was assessed according to the criteria of the COSMIN checklist. The search yielded 3,524 results, seven of which were included in the review. Six questionnaires assessing motivations for weight loss, which could be applied to various age groups, were identified. All the questionnaires presented items related to appearance and health as the main motivation for weight loss. In addition to these motivations, the questionnaires also included items related to improved sports performance, self-confidence, participation in important social events, family and social pressure, and fitting into different clothes. The most evaluated measurement properties in the studies were internal consistency, reliability, content validity, and construct validity. Regarding internal consistency, one was rated as excellent, one as fair, and three as poor. For reliability, two were rated as being of fair quality, and one as of poor quality. Two studies analyzed the content validity and the questionnaires were rated as being of poor methodological quality. Regarding structural validity, one was rated as excellent, another as fair, and another as poor quality. Only the Weight Loss Motivation Questionnaire presented excellent methodological quality for most of the analyzed criteria. There is a need to develop questionnaires that are of better methodological quality to assess motivations for weight loss. Instruments targeting the adolescent population should also be developedArtigo Instruments for evaluation of motivations for weight loss in individuals with overweight and obesity: a systematic review and narrative synthesis(Plos one, 2019) Lima, Severina Carla Vieira Cunha; Silva, David Franciole Oliveira; Evangelista, Karine Cavalcanti Maurício Sena; Lyra, Clélia Oliveira; Pedrosa, Lucia Fátima Campos; Arrais, Ricardo Fernando; https://orcid.org/0000-0001-8268-1986This systematic review aims to identify instruments used to assess motivations for weight loss in individuals with overweight and obesity from different age groups, such as children, adolescents, adults, and older adults. The virtual search was carried out using the PubMed, Scopus, LILACS, and ADOLEC databases, and by manual search. The following descriptors were used: questionnaire, scale, instrument, evaluation, motivation, motive, reason, “lose weight,” “losing weight,” “weight loss,” and slimming. Methodological quality was assessed according to the criteria of the COSMIN checklist. The search yielded 3,524 results, seven of which were included in the review. Six questionnaires assessing motivations for weight loss, which could be applied to various age groups, were identified. All the questionnaires presented items related to appearance and health as the main motivation for weight loss. In addition to these motivations, the questionnaires also included items related to improved sports performance, self-confidence, participation in important social events, family and social pressure, and fitting into different clothes. The most evaluated measurement properties in the studies were internal consistency, reliability, content validity, and construct validity. Regarding internal consistency, one was rated as excellent, one as fair, and three as poor. For reliability, two were rated as being of fair quality, and one as of poor quality. Two studies analyzed the content validity and the questionnaires were rated as being of poor methodological quality. Regarding structural validity, one was rated as excellent, another as fair, and another as poor quality. Only the Weight Loss Motivation Questionnaire presented excellent methodological quality for most of the analyzed criteria. There is a need to develop questionnaires that are of better methodological quality to assess motivations for weight loss. Instruments targeting the adolescent population should also be developed.Artigo Lack of association between inadequate micronutrient intake and prognosis in outpatients with heart failure(Nutrients, 2022) Lima, Severina Carla Vieira Cunha; Torres, Núbia Rafaella Soares Moreira; Freire, Fernanda Lambert de Andrade; Komatsu, Raquel Costa Silva Dantas; Silva, Eduardo Paixão da; Queiroz, Salomão Israel Monteiro Lourenço; Lira, Niethia Regina Dantas de; Diniz, Rosiane Viana Zuza; Pedrosa, Lucia Fatima Campos; Lopes, Márcia Marília Gomes Dantas; Evangelista, Karine Cavalcanti Maurício Sena; https://orcid.org/0000-0001-8268-1986Inadequate nutrient intake can lead to worse outcomes in patients with heart failure (HF). This prospective cohort study aimed to assess the prevalence of inadequate micronutrient intake and their association with prognosis in 121 adult and elderly outpatients with HF. Habitual micronutrient intake was evaluated using 24-h dietary recalls (minimum 2 and maximum 6). Participants were grouped into moderate (n = 67) and high (n = 54) micronutrient deficiency groups, according to the individual assessment of each micronutrient intake. Patients’ sociodemographic, clinical, and anthropometric data and clinical outcomes (hospitalization and mortality) within 24 months were collected. Overall and event-free survival rates were calculated using Kaplan–Meier estimates, and curves were compared using the log-rank test. The death risk rate (hazard ratio (HR)) was calculated using Cox’s univariate model. The rate of inadequate intake was 100% for vitamins B1 and D and above 80% for vitamins B2, B9, and E, calcium, magnesium, and copper. No differences in overall survival and event-free survival were observed between groups of HF outpatients with moderate and high micronutrient deficiencies (HR = 0.94 (CI = 0.36–2.48), p = 0.91, and HR = 1.63 (CI = 0.68–3.92), p = 0.26, respectively), as well as when the inadequacy of each micronutrient intake was evaluated alone (all p > 0.05). In conclusion, a high prevalence of inadequate micronutrient intake was observed in outpatients with HF. Inadequate micronutrient intake was not associated with hospitalization and mortality in this group of patients.Artigo Lack of association between inadequate micronutrient Intake and prognosis in outpatients with heart failure(Nutrients, 2022) Lopes, Márcia Marília Gomes Dantas; Torres, Núbia Rafaella Soares Moreira; Freire, Fernanda Lambert de Andrade; Komatsu, Raquel Costa Silva Dantas; Silva, Eduardo Paixão da; Queiroz, Salomão Israel Monteiro Lourenço; Lira, Niethia Regina Dantas de; Diniz, Rosiane Viana Zuza; Lima, Severina Carla Vieira Cunha; Pedrosa, Lucia Fatima Campos; Evangelista, Karine Cavalcanti Maurício Sena; https://orcid.org/0000-0002-0011-576XInadequate nutrient intake can lead to worse outcomes in patients with heart failure (HF). This prospective cohort study aimed to assess the prevalence of inadequate micronutrient intake and their association with prognosis in 121 adult and elderly outpatients with HF. Habitual micronutrient intake was evaluated using 24-h dietary recalls (minimum 2 and maximum 6). Participants were grouped into moderate (n = 67) and high (n = 54) micronutrient deficiency groups, according to the individual assessment of each micronutrient intake. Patients’ sociodemographic, clinical, and anthropometric data and clinical outcomes (hospitalization and mortality) within 24 months were collected. Overall and event-free survival rates were calculated using Kaplan–Meier estimates, and curves were compared using the log-rank test. The death risk rate (hazard ratio (HR)) was calculated using Cox’s univariate model. The rate of inadequate intake was 100% for vitamins B1 and D and above 80% for vitamins B2, B9, and E, calcium, magnesium, and copper. No differences in overall survival and event-free survival were observed between groups of HF outpatients with moderate and high micronutrient deficiencies (HR = 0.94 (CI = 0.36–2.48), p = 0.91, and HR = 1.63 (CI = 0.68–3.92), p = 0.26, respectively), as well as when the inadequacy of each micronutrient intake was evaluated alone (all p > 0.05). In conclusion, a high prevalence of inadequate micronutrient intake was observed in outpatients with HF. Inadequate micronutrient intake was not associated with hospitalization and mortality in this group of patients.Artigo Motivations for weight loss in adolescents with overweight and obesity: a systematic review(BMC Pediatrics, 2018) Lima, Severina Carla Vieira Cunha; Silva, David Franciole Oliveira; Evangelista, Karine Cavalcanti Maurício Sena; Lyra, Clélia Oliveira; Pedrosa, Lucia Fátima Campos; Arrais, Ricardo Fernando; https://orcid.org/0000-0001-8268-1986Background: Adolescents with overweight and obesity report various motivations for weight loss other than the desire for better health. However, there is little evidence regarding the main motivations for weight loss in adolescents. The present systematic review aimed to identify the motivations for weight loss in adolescents with overweight and obesity. Methods: A systematic search for original articles published up to December 2016 was carried out in the PubMed, Scopus, LILACS, and ADOLEC databases. The terms used in the search were: motivation, motive, reason, “weight loss,” “lose weight,” and adolescent. Results: Six studies (all cross-sectional) met the selection criteria and were included in the review. The instruments used to assess the participants’ motivations for weight loss were interviews and questionnaires with open questions. Seventeen motivations for weight loss were identified, the main ones being better health, esthetic/ cosmetic reasons, improvements in self-esteem, and avoidance of provocation/bullying. Conclusions: The results of the present review show the need for validated instruments to assess the motivations for weight loss in adolescents with overweight and obesity. Moreover, the high frequency of motivations for weight loss related to appearance and social acceptance evidences the need for multidisciplinary weight loss interventions that consider not only the biological factors, but also the psychological and social aspects.Artigo Motivations for weight loss in adolescents with overweight and obesity: a systematic review(BMC Pediatrics, 2018-11) Lyra, Clélia de Oliveira; Silva, David Franciole Oliveira; Evangelista, Karine Cavalcanti Maurício Sena; Pedrosa, Lucia Fátima Campos; Arrais, Ricardo Fernando; Lima, Severina Carla Vieira CunhaBackground: Adolescents with overweight and obesity report various motivations for weight loss other than the desire for better health. However, there is little evidence regarding the main motivations for weight loss in adolescents. The present systematic review aimed to identify the motivations for weight loss in adolescents with overweight and obesity. Methods: A systematic search for original articles published up to December 2016 was carried out in the PubMed, Scopus, LILACS, and ADOLEC databases. The terms used in the search were: motivation, motive, reason, “weight loss,” “lose weight,” and adolescent. Results: Six studies (all cross-sectional) met the selection criteria and were included in the review. The instruments used to assess the participants’ motivations for weight loss were interviews and questionnaires with open questions. Seventeen motivations for weight loss were identified, the main ones being better health, esthetic/ cosmetic reasons, improvements in self-esteem, and avoidance of provocation/bullying. Conclusions: The results of the present review show the need for validated instruments to assess the motivations for weight loss in adolescents with overweight and obesity. Moreover, the high frequency of motivations for weight loss related to appearance and social acceptance evidences the need for multidisciplinary weight loss interventions that consider not only the biological factors, but also the psychological and social aspectsArtigo Plasma lipid metabolites as potential biomarkers for identifying individuals at risk of obesity-induced metabolic complications(Scientific Reports, 2023) Lima, Severina Carla Vieira Cunha; Bellot, Paula Emília Nunes Ribeiro; Braga, Erik Sobrinho; Omage, Folorunsho Bright; Nunes, Francisca Leide da; Lyra, Clélia Oliveira; Marchioni, Dirce Maria Lobo; Pedrosa, Lucia Fatima Campos; Barbosa Júnior, Fernando; Tasic, Ljubica; Evangelista, Karine Cavalcanti Maurício Sena; https://orcid.org/0000-0001-8268-1986Lipidomics studies have indicated an association between obesity and lipid metabolism dysfunction. This study aimed to evaluate and compare cardiometabolic risk factors, and the lipidomic profile in adults and older people. A cross-sectional study was conducted with 72 individuals, divided into two sex and age-matched groups: obese (body mass index—BMI ≥ 30 kg/m2; n = 36) and non-obese (BMI < 30 kg/m2; n = 36). The lipidomic profiles were evaluated in plasma using 1H nuclear magnetic resonance (1H-NMR) spectroscopy. Obese individuals had higher waist circumference (p < 0.001), visceral adiposity index (p = 0.029), homeostatic model assessment insulin resistance (HOMA-IR) (p = 0.010), and triacylglycerols (TAG) levels (p = 0.018). 1H-NMR analysis identified higher amounts of saturated lipid metabolite fragments, lower levels of unsaturated lipids, and some phosphatidylcholine species in the obese group. Two powerful machine learning (ML) models—k-nearest neighbors (kNN) and XGBoost (XGB) were employed to characterize the lipidomic profile of obese individuals. The results revealed metabolic alterations associated with obesity in the NMR signals. The models achieved high accuracy of 86% and 81%, respectively. The feature importance analysis identified signal at 1.50–1.60 ppm (–CO–CH2–CH2–, Cholesterol and fatty acid in TAG, Phospholipids) to have the highest importance in the two models.Artigo Plasma lipid metabolites as potential biomarkers for identifying individuals at risk of obesity-induced metabolic complications(Scientific Reports, 2023-07) Lyra, Clelia de Oliveira; Bellot, Paula Emília Nunes Ribeiro; Braga, Erik Sobrinho; Omage, Folorunsho Bright; Nunes, Francisca Leide da Silva; Lima, Severina Carla Vieira Cunha; Marchioni, Dirce Maria Lobo; Pedrosa, Lucia Fatima Campos; Barbosa, Fernando; Tasic, Ljubica; Evangelista, Karine Cavalcanti Maurício SenaLipidomics studies have indicated an association between obesity and lipid metabolism dysfunction. This study aimed to evaluate and compare cardiometabolic risk factors, and the lipidomic profle in adults and older people. A cross-sectional study was conducted with 72 individuals, divided into two sex and age-matched groups: obese (body mass index—BMI≥ 30 kg/m2 ; n= 36) and nonobese (BMI < 30 kg/m2 ; n= 36). The lipidomic profles were evaluated in plasma using 1 H nuclear magnetic resonance (1 H-NMR) spectroscopy. Obese individuals had higher waist circumference (p< 0.001), visceral adiposity index (p= 0.029), homeostatic model assessment insulin resistance (HOMA-IR) (p= 0.010), and triacylglycerols (TAG) levels (p= 0.018). 1 H-NMR analysis identifed higher amounts of saturated lipid metabolite fragments, lower levels of unsaturated lipids, and some phosphatidylcholine species in the obese group. Two powerful machine learning (ML) models—knearest neighbors (kNN) and XGBoost (XGB) were employed to characterize the lipidomic profle of obese individuals. The results revealed metabolic alterations associated with obesity in the NMR signals. The models achieved high accuracy of 86% and 81%, respectively. The feature importance analysis identifed signal at 1.50–1.60 ppm (–CO–CH2–CH2–, Cholesterol and fatty acid in TAG, Phospholipids) to have the highest importance in the two modelsArtigo Processed and ultra-processed foods are associated with high prevalence of inadequate selenium intake and low prevalence of vitamin B1 and zinc inadequacy in adolescents from public schools in an urban area of northeastern Brazil(PLoS One, 2019-12) Lyra, Clélia de Oliveira; Falcão, Raphaela Cecília Thé Maia de Arruda; Morais, Célia Márcia Medeiros de; Pinheiro, Liana Galvão Bacurau; Pedrosa, Lucia Fátima Campos; Lima, Severina Carla Vieira Cunha; Evangelista, Karine Cavalcanti Maurício SenaChanges in eating behavior of adolescents are associated with high consumption of processed and ultra-processed foods. This study evaluated the association between these foods and the prevalence of inadequate micronutrient intake in adolescents. A cross-sectional study was conducted with 444 adolescents from public schools in the city of Natal, northeastern Brazil. The adolescents’ habitual food consumption was evaluated using two 24-hour dietary recalls. Foods were categorized according to the degree of processing (processed and ultra-processed) and distributed into energy quartiles, using the NOVA classification system. Inadequacies in micronutrient intake were assessed using the estimated average requirement (EAR) as the cutoff point. Multivariate logistic regression models were used to estimate the relationship between energy percentage from processed and ultra-processed foods and prevalence of inadequate micronutrient intake. The mean (Standard Deviation (SD)) consumption of total energy from processed foods ranged from 5.8% (1.7%) in Q1 to 20.6% (2.9%) in Q4, while the mean consumption of total energy from ultra-processed foods ranged from 21.4% (4.9%) in Q1 to 61.5% (11.7%) in Q4. The rates of inadequate intake of vitamin D, vitamin E, folate, calcium, and selenium were above 80% for both sexes across all age groups. Energy consumption from processed foods was associated with higher prevalence of inadequate selenium intake (p < 0.01) and lower prevalence of inadequate vitamin B1 intake (p = 0.04). Energy consumption from ultra-processed foods was associated with lower prevalence of inadequate zinc and vitamin B1 intake (p < 0.01 and p = 0.03, respectively). An increase in the proportion of energy obtained from processed and ultra-processed foods may reflect higher prevalence of inadequate selenium intake and lower prevalence of vitamin B1 and zinc inadequacy