Navegando por Autor "Eijk, Annemiek A."
Agora exibindo 1 - 1 de 1
- Resultados por página
- Opções de Ordenação
Artigo Antecedent infections in Guillain-Barré syndrome in endemic areas of arbovirus transmission: a multinational case-control study(Wiley, 2021) Dourado Junior, Mário Emílio Teixeira; Leonhard, Sonja E.; Tan, heng Yin; Leonhard, Sonja E; Tan, Cheng Yin; Eijk, Annemiek A.; Reisin, Ricardo R.; Franken, Suzanne C.; Huizinga, Ruth; Arends, Samuel; Batstra, Manou R.; Jeronimo, Selma M. Bezerra; Drenthen, Judith; https://orcid.org/0000-0002-9462-2294Half of the world's population is at risk of arthropod-borne virus (arbovirus) infec-tions. Several arbovirus infections have been associated with Guillain-Barré syn-drome (GBS). We investigated whether arboviruses are driving GBS beyond epidemicphases of transmission and studied the antibody response to glycolipids. The proto-col of the International Guillain-Barré syndrome Outcome Study (IGOS), an observa-tional prospective cohort study, was adapted to a case-control design. Serumsamples were tested for a recent infection with Zika virus (ZIKV), dengue virus(DENV), chikungunya (CHIKV) virus, hepatitis E virus, Epstein-Barr virus (EBV), cyto-megalovirus (CMV),Campylobacter jejuni, andMycoplasma pneumoniae, and for anti-bodies to glycolipids. Forty-nine patients were included from Brazil (63%), Argentina(14%), and Malaysia (22%). Evidence of a recent infection was found in 27/49 (55%)patients:C jejuni(n=15, 31%),M pneumoniae(n=5, 10%), CHIKV (n=2, 4%), EBV(n=1, 2%),C jejuniandM pneumoniae(n=2, 4%), CMV and DENV (n=1, 2%), andC jejuniand DENV (n=1, 2%). In 22 patients, 35 paired controls were collected.Odds ratio for recent infections did not significantly differ between cases and con-trols. No typical anti-ganglioside antibody binding was associated with recent arbovi-rus infection. We conclude that arbovirus infections occur in GBS patients outside ofepidemic viral transmission, although not significantly more than in controls. Broadinfection and anti-ganglioside antibody serology are important to establish the mostlikely pathogenic trigger in GBS patients. Larger studies are necessary to determinethe association between arboviruses and GBS.