Navegando por Autor "Dorman, Guido"
Agora exibindo 1 - 2 de 2
- Resultados por página
- Opções de Ordenação
Artigo Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory(2013) Katche, Cynthia; Dorman, Guido; Slipczuk, Leandro; Cammarota, Martín Pablo; Medina, Jorge H.Memory storage is a temporally graded process involving different phases and different structures in the mammalian brain. Cortical plasticity is essential to store stable memories, but little is known regarding its involvement in memory processing. Here we show that fear memory consolidation requires early post-training macromolecular synthesis in the anterior part of the retrosplenial cortex (aRSC), and that reversible pharmacological inactivation of this cortical region impairs recall of recent as well as of remote memories. These results challenge the generally accepted idea that neocortical areas are slow encoding systems that participate in the retrieval of remote memories only.Artigo On the Role of Retrosplenial Cortex in Long-Lasting Memory Storage(2013) Katche, Cynthia; Dorman, Guido; Gonzalez, Carolina; Kramar, Cecilia P.; Slipczuk, Leandro; Rossato, Janine I.; Cammarota, Martín Pablo; Medina, Jorge H.The retrosplenial cortex (RSC) is involved in a range of cognitive functions. However, its precise involvement in memory processing is unknown. Pharmacological and behavioral experiments demonstrate that protein synthesis and c-Fos expression in the anterior part of RSC (aRSC) are necessary late after training to maintain for many days a fear-motivated memory. Long-lasting memory storage is regulated by D1/ D5 dopamine receptors in aRSC and depends on the functional interplay between dorsal hippocampus and aRSC. These results suggest that the RSC recapitulates some of the molecular events that occur in the hippocampus to maintain memory trace over time.