Navegando por Autor "Dias, Paula Cristina Silveira"

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Avaliação do status de zinco e da expressão gênica de metalotioneínas em pacientes com aterosclerose tratados com rosuvastatina
(Universidade Federal do Rio Grande do Norte, 2011-02-22) Dias, Paula Cristina Silveira; Schwarzschild, Lúcia de Fátima Campos Pedrosa; ; http://lattes.cnpq.br/1863589790139155; ; http://lattes.cnpq.br/0066564403217916; Rezende, Adriana Augusto de; ; http://lattes.cnpq.br/4245215108740331; Rebecchi, Ivanise Marina Moretti; ; http://lattes.cnpq.br/7308186244207080; Ong, Thomas Prates; ; http://lattes.cnpq.br/2216436678930586
O estudo teve como objetivo avaliar o status de zinco por meio da ingestão dietética, zinco no plasma e nos eritrócitos e a expressão gênica das metalotioneínas em pacientes com aterosclerose em uso de rosuvastatina. A pesquisa envolveu 27 pacientes adultos e idosos de ambos os sexos com aterosclerose que foram tratados com rosuvastatina (10mg/dia) durante 4 meses. Foi realizada a dosagem do perfil lipídico, glicemia, AST e ALT, proteína C reativa ultrasensível (PCRus), zinco plasmático e eritrocitário e expressão gênica das metalotioneínas 1 e 2. Realizou-se a avaliação do índice de massa corporal (IMC) e circunferência abdominal (CA), além da análise do consumo alimentar dos pacientes. A maioria dos pacientes avaliados apresentou sobrepeso, tanto antes como após o tratamento, sem diferença significativa entre os tempos do estudo. Identificou-se que a CA foi reduzida significativamente no grupo (p<0,05) após a intervenção. A maioria dos pacientes tinha ingestão abaixo da recomendação de calorias e fibras e acima do recomendado de proteínas. As gorduras mono e poliinsaturadas foram adequadas para a maioria dos pacientes, no entanto, a gordura saturada e colesterol foram consumidos em excesso por grande parte dos indivíduos. O consumo de zinco foi inadequado, constatando-se 100% de inadequação no sexo masculino e 84% no feminino. Após o tratamento com a rosuvastatina houve redução significativa do colesterol total (CT) e LDL-c (p<0,01) e não foram observadas alterações no HDL-c e triacilglicérides. Foi verificada também a redução da glicemia (p<0,05) e da PCRus (p<0,01). As análises não demonstraram diferenças significativas nas concentrações de zinco no plasma nem nos eritrócitos antes e após o tratamento com rosuvastatina. Houve, após o tratamento, redução do gene MT1F (p<0,05) sem, no entanto, ocorrer alteração significativa do gene MT2A. O tratamento com rosuvastatina foi efetivo na redução do CT e LDL-c, bem como promoveu a redução do marcador inflamatório PCRus. O zinco no plasma e nos eritrócitos não foi alterado pelo uso da medicamento e houve uma redução do gene MT1F, possivelmente em função da redução da inflamação. A maioria dos pacientes apresentou consumo inadequado de zinco e esta inadequação não teve relação com os parâmetros do mineral no plasma ou nos eritrócitos nem com a expressão gênica das metalotioneínas
The beneficial effects of rosuvastatin are independent of zinc supplementation in patients with atherosclerosis
(Journal of Trace Elements in Medicine and Biology, 2014-04) Evangelista, Karine Cavalcanti Maurício de Sena; Dias, Paula Cristina Silveira; Paiva, Maria Sanali Moura de Oliveira; Ferreira, Diana Quitéria Cabral; Ururahy, Marcela Abbott Galvão; Rezende, Adriana Augusto; Abdalla, Dulcinéia Saes Parra; Pedrosa, Lucia Fatima Campos
Background: Statins have multiple antiatherosclerotic effects, but can reduce blood plasma concentrations of minerals, including zinc. As zinc possesses antiinflammatory and antioxidant effects, low zinc status can promote injuries or inadequate tissue repair in endothelial cells. Metallothionein (MT) expression might modulate responses induced by statins in patients with atherosclerosis. However, research regarding mineral status and the use of statins is scarce. This study evaluated the effects of zinc supplementation on zinc status and expression of the zinc-dependent MT1F and MT2A genes in patients with atherosclerosis treated with rosuvastatin. Methods: A double-blind, randomized clinical trial was performed with 54 participants treated with 10 mg rosuvastatin for 4 months with or without zinc supplementation (30 mg/day). Diet, lipid profile, high-sensitivity reactive protein C (hs-CRP), plasma and erythrocyte zinc concentrations, erythrocyte superoxide dismutase (SOD) activity, and MT1F and MT2A genes expression were analyzed before and after intervention. Results: Rosuvastatin therapy was effective in reducing low- and non-high-density lipoprotein, total cholesterol, triglycerides, and hs-CRP levels, independent of zinc supplementation. Additionally, zinc treatment had no effect on SOD enzyme activity (P = 0.201), plasma (P > 0.671) and erythrocyte (P > 0.123) zinc concentrations, or the pattern of MT1F and MT2A genes expression (P = 0.088 and P = 0.229, respectively). Conclusions: The effectiveness of rosuvastatin treatment is independent of the effects of zinc supplementation. Moreover, rosuvastatin treatment did not have a significant impact on zinc status or MT1F and MT2A genes expression in patients with atherosclerosis
The hypolipidemic and pleiotropic effects of rosuvastatin are not enhanced by its association with zinc and selenium supplementation in coronary artery disease patients: a double blind randomized controlled study
(Plos One, 2015-03) Evangelista, Karine Cavalcanti Maurício Sena; Pedrosa, Lucia Fatima Campos; Paiva, Maria Sanali Moura Oliveira; Dias, Paula Cristina Silveira; Ferreira, Diana Quitéria Cabral; Cozzolino, Sílvia Maria Franciscato; Faulin, Tanize Espírito Santo; Abdalla, Dulcinéia Saes Parra
Objective: Statins treatment may modify the levels of zinc and selenium, minerals that can improve vascular function and reduce oxidative damage and inflammation in atherosclerotic patients. This study aimed to evaluate the effects of rosuvastatin, alone or associated with zinc and selenium supplementation, on lipid profile, antioxidant enzymes and mineral status in coronary artery disease patients. Material and Methods A double-blind randomized clinical trial was performed in which patients (n = 76) were treated with 10 mg rosuvastatin over 4 months associated or not with zinc (30 mg/d) and selenium (150 μg/d) supplementation. The following parameters were analyzed before and after the intervention: anthropometric measurements, lipid profile, high sensitivity C-reactive protein (hs-CRP), electronegative low density lipoprotein (LDL(-)) concentrations, activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), zinc and selenium concentrations in blood plasma and erythocytes. Significance was determined using an α of 5% (twotailed). Results We found that rosuvastatin therapy was efficient in reducing total cholesterol, LDL-cholesterol, non-HDL cholesterol, triglycerides, and hs-CRP independently of mineral supplementation. Neither treatment was associated with significant changes in LDL(-). Similarly, the antioxidant enzymes GPx and SOD activity were unchanged by treatments. Neither treatment was associated with significant differences in concentrations of zinc or selenium in blood plasma and erythocytes of studied groups. Conclusion Rosuvastatin treatment did not affect zinc and selenium levels in coronary artery disease patients. The zinc and selenium supplementation at doses used in this study did not change lipid profile or SOD and GPx activity in patients receiving rosuvastatin. Further studies should be focused on testing alternative doses and supplements in different populations to contribute for a consensus on the ideal choice of antioxidants to be used as possible complementary therapies in atherosclerotic patients

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Navegando por Autor "Dias, Paula Cristina Silveira"