Navegando por Autor "Cobucci, Ricardo Ney"

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Effects of supplementation with probiotics in experimental models of alzheimer's disease: a systematic review of animal experiments
(Bentham Science Publishers, 2022-04-06) Idalina Neta, Francisca; Souza, Francisco Emílio Simplício de; Batista, André Lima; Pinheiro, Francisco Irochima; Cobucci, Ricardo Ney; Guzen, Fausto Pierdoná
Background: Conditions along the brain-gut-microbiota (BGM) axis can significantly contribute to the pathogenesis of Alzheimer's disease (AD). Evidence from animal studies indicates a role of probiotics in regulating mood, cognition, and stress response via the BGM axis. However, the effect of probiotics on AD needs to be better clarified in preclinical and clinical studies. Methods : We prepared this systematic review according to PRISMA. PubMed, Web of Science, Embase, and Virtual Health Library (VHL) were searched for original articles concerning the effects of probiotics in experimental AD. Results: Results were presented as a narrative synthesis according to the Synthesis Without Metaanalysis (SWiM) Guideline. Seventeen studies met the inclusion criteria. The results showed significant effects in the experimental models of AD treated with probiotics alone or in mixture due to expressive improvements in cognitive tests. Conclusion: Furthermore, in most of the included studies, it was possible to observe a reduction in inflammatory processes, an increase in the concentration of peptide hormones, insulin homeostasis in the brain, increased antioxidant enzymes, and a decrease in beta-amyloid deposition and tau hyperphosphorylation. Supplementation of probiotics seems to improve performance in cognitive tests and increase the concentration of substances capable of delaying the neurodegenerative process of AD in experimental models.
Effects of vitamin D supplementation on cardiometabolic parameters among patients with metabolic syndrome: a systematic review and grade evidence synthesis of randomized controlled trials
(Heliyon, 2023-11) Evangelista, Karine Cavalcanti Maurício de Sena; Aquino, Séphora; Cunha, Aline; Lima, Josivan Gomes; Oliveira, Antonio Gouveia; Cobucci, Ricardo Ney; Pedrosa, Lucia Fatima Campos
Various pathophysiologic mechanisms were proposed to underlie the effect of vitamin D on MetS components. In this systematic review, we reviewed randomized control clinical trials to verify whether vitamin D supplementation (VDS) at different doses is effective concomitantly in controlling high-density lipoprotein cholesterol (HDL-c), triglycerides (TG), fasting glucose level, blood pressure, and central obesity in adults diagnosed with MetS. The following scientific databases were searched from 1998 until April 2023: EMBASE, MEDLINE (PubMed), Web of Science, Latin American and Caribbean Health Sciences Literature (Lilacs), the Cochrane Central Register of Controlled Trials, clinicaltrial.gov, and Google Scholar. No language restrictions were applied. Seven studies were included, and they showed a high level of heterogeneity. All studies reported a significant increase in serum 25(OH)D levels in the intervention groups. Of these, only two noted a significant decrease in triglyceride (TG) level and waist circumference. However, the certainty levels of the evidence rating were very low and low for triglyceride (TG) level and waist circumference, respectively, and moderate for fasting glucose level, blood pressure, and HDL-c. In conclusion, despite these benefits, considering the low certainty, the evidence does not support that VDS decreases triglyceride (TG) level and waist circumference in adults with MetS
Effects of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with metabolic syndrome: a protocol for systematic review and meta-analysis of randomized controlled trials
(Systematic Reviews, 2020-08) Evangelista, Karine Cavalcanti Maurício de Sena; Aquino, Séphora Louyse Silva; Cunha, Aline Tuane Oliveira; Lima, Josivan Gomes; Oliveira, Antonio Gouveia; Cobucci, Ricardo Ney; Pedrosa, Lucia Fatima Campos
Background: Vitamin D deficiency can play a role in extraskeletal functions that are involved with a set of risk factors associated with metabolic syndrome (MetS). The purpose of this review is to investigate the impact of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with MetS. Methods: EMBASE, Medline, Web of Science, Lilacs, the Cochrane Central Register of Controlled Trials, clinicaltrials.gov databases, and grey literature will be systematically searched for randomized controlled trials (RCTs) of vitamin D supplementation compared with placebo, through December 2020. We will include in the study patients with MetS diagnosed by the criteria set forth by the National Cholesterol Education Program Adult Treatment Panel III or the International Diabetes Federation. The effect of oral vitamin D supplementation on lipid profile improvement (triglycerides, high-density lipoprotein cholesterol—HDL-C) is this review’s primary outcome. The systematic review will be performed following the Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA) guidelines. The study screening, data extraction, and quality assessment will be fulfilled by two independent reviewers according to the Cochrane Risk of Bias tool (RoB 2.0). The results of the systematic review will be provided according to the type of intervention, characteristics of the target population, the methods of measurement of vitamin D, the calculated vitamin D concentrations, types of biological samples, and types of outcomes. Meta-analyses will be conducted where appropriate. The Cochran’s Q test and the I 2 -heterogeneity test will be used to assess the presence of heterogeneity and whether the fixed or the random-effects model would be appropriate for combining study results using the inverse variance method or the DerSimonian-Lair method, respectively. Publication bias will be evaluated using funnel plots and Egger’s and Begg’s tests. The strength of the evidence will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Discussion: This systematic review will assess the effects of vitamin D supplementation on fasting glucose and triglyceride levels, waist circumference and mean blood pressure, and HDL-C among individuals with MetS. These findings may assist with decision-making within a clinical setting
Estudo de polimorfismos na região promotora do gene IL-10 em mulheres com lesão intraepitelial e cancêr cervical
(Universidade Federal do Rio Grande do Norte, 2019-06-06) Santos, Deborah Luisa de Sousa; Freitas, Janaina Cristiana de Oliveira Crispim; Cobucci, Ricardo Ney; Oliveira, Ana Katherine Da Silveira Goncalves de
No Brasil, o câncer cervical ocupa a terceira posição no ranking de incidência de câncer na população feminina. O Papilomavírus Humano (HPV) é o principal agente causador do câncer cervical e lesões precursoras, e é importante destacar que muitas vezes o HPV utiliza estratégias para se evadir da resposta imunológica utilizando mecanismo que envolvam imunorregulação. No microambiente tumoral, tem-se destacado algumas moléculas imunorreguladoras e as mesmas têm contribuído para progressão do câncer cervical. A IL-10 é uma citocina imunossupressora, frequentemente elevada no microambiente tumoral. O gene que codifica a IL-10 humana está localizado no cromossomo 1 (1q31-32). Também foram identificados polimorfismos de base única (SNPs) na região promotora de IL-10 que podem influenciar a produção da citocina, e consequentemente desempenhar um papel na susceptibilidade ao câncer. Neste estudo foram analisados os SNPs -1082A>G ( rs1800896 ) e -819C>T ( rs1800871 ) do gene IL-10 , a partir de amostras de sangue periférico de 317 mulheres brasileiras, sendo 142 mulheres com alteração no colo do útero (grupo alterado), enquadradas com lesão intraepitelial cervical (SIL) (n=101, sendo 24 pacientes com lesão de baixo grau e 77 com lesão de alto grau) e câncer cervical (CC) (n=41), e 167 mulheres saudáveis representando o grupo controle. O objetivo foi verificar a frequência alélica e genotípica dos SNPs da região prmotora da IL-10 e associar com desenvolvimento de SIL e CC. Como resultado, no polimorfismo rs1800896 , a frequência do genótipo GG foi estatisticamente menor no grupo alterado (SIL e CC) e no grupo SIL, comparados ao grupo controle (OR = 0,35, CI 95% = 0,14 - 0,88, e p=0,026; OR = 0,36, CI 95% = 0,13 - 1,00, e p=0,049, respectivamente). O grupo CC, comparado ao controle, não mostrou nenhuma diferença significativa, assim como não houve diferença estatística entre os casos e controle no polimorfismo rs1800871 (p>0,05). Desta forma, conclui-se que, no polimorfismo rs1800896 , o genótipo GG apresentou não estar associado ao desenvolvimento de SIL e câncer cervical.
Magnetic device for closing skin wounds
(Research, Society and Development, 2020-11-11) Pinheiro, Gleyse Karina Lopes de Oliveira; Batista, André Lima; Cobucci, Ricardo Ney; Rêgo, Amália Cinthia Meneses; Araújo-Filho, Irami; Guzen, Fausto Pierdoná; Pinheiro, Francisco Irochima; https://orcid.org/0000-0001-5264-3620
The attempt to repair skin wounds dates back many years. We have observed bone fragments for making needles, hair, fibers, and animal tissues as sutures and even applying sensors to accelerate the healing process throughout history. Despite all the developments, the need for a qualified professional and prior local anesthesia to perform the suture still represent obstacles. The present study aimed to create 3D printing pieces containing N42 neodymium magnets to be fixed to the skin with adhesive tape to promote skin wounds' closure without the need for anesthesia. A descriptive, experimental study was carried out, divided into the Patent search, Ideation and creation, 3D Modeling, 3D printing of structural parts, Assembly, and Testing on artificial skin. ABSplus® plastic parts were created through 3D printing that received N42 neodymium magnets and the application of a double-sided adhesive to attach to the skin. A perilesional arrangement was simulated with the pieces created using an artificial skin model (EasySuture® Standart) after making the incision. After applying the pieces containing N42 neodymium, there was a perfect coaptation of the lesion's edges without detecting interspersed spaces in the longitudinal axis of the incision. The research resulted in creating a prototype that needs improvements and industrial adaptations for viable use in surgical practice.
Nutritional risk screening tools for older adults with COVID-19: a systematic review
(Nutrients, 2020-09) Evangelista, Karine Cavalcanti Maurício de Sena; Silva, David Franciole Oliveira; Lima, Severina Carla Vieira Cunha; Marchioni, Dirce Maria; Cobucci, Ricardo Ney; Andrade, Fábia Barbosa de
Abstract: Coronavirus disease 2019 (COVID-19) is associated with high risk of malnutrition, primarily in older people; assessing nutritional risk using appropriate screening tools is critical. This systematic review identified applicable tools and assessed their measurement properties. Literature was searched in the MEDLINE, Embase, and LILACS databases. Four studies conducted in China met the eligibility criteria. Sample sizes ranged from six to 182, and participants’ ages from 65 to 87 years. Seven nutritional screening and assessment tools were used: the Nutritional Risk Screening 2002 (NRS-2002), the Mini Nutritional Assessment (MNA), the MNA-short form (MNA-sf), the Malnutrition Universal Screening Tool (MUST), the Nutritional Risk Index (NRI), the Geriatric NRI (GNRI), and modified Nutrition Risk in the Critically ill (mNUTRIC) score. Nutritional risk was identified in 27.5% to 100% of participants. The NRS-2002, MNA, MNA-sf, NRI, and MUST demonstrated high sensitivity; the MUST had better specificity. The MNA and MUST demonstrated better criterion validity. The MNA-sf demonstrated better predictive validity for poor appetite and weight loss; the NRS-2002 demonstrated better predictive validity for prolonged hospitalization. mNUTRIC score demonstrated good predictive validity for hospital mortality. Most instruments demonstrate high sensitivity for identifying nutritional risk, but none are acknowledged as the best for nutritional screening in older adults with COVID-19
Nutritional risk screening tools for older adults with COVID-19: a systematic review
(Nutrients, 2020) Lima, Severina Carla Vieira Cunha Lima; Silva, David Franciole Oliveira Silva; Evangelista, Karine Cavalcanti Mauricio Sena; Marchioni, Dirce Maria; Cobucci, Ricardo Ney; Andrade, Fábia Barbosa de; https://orcid.org/0000-0001-8268-1986
Coronavirus disease 2019 (COVID-19) is associated with high risk of malnutrition, primarily in older people; assessing nutritional risk using appropriate screening tools is critical. This systematic review identified applicable tools and assessed their measurement properties. Literature was searched in the MEDLINE, Embase, and LILACS databases. Four studies conducted in China met the eligibility criteria. Sample sizes ranged from six to 182, and participants’ ages from 65 to 87 years. Seven nutritional screening and assessment tools were used: the Nutritional Risk Screening 2002 (NRS-2002), the Mini Nutritional Assessment (MNA), the MNA-short form (MNA-sf), the Malnutrition Universal Screening Tool (MUST), the Nutritional Risk Index (NRI), the Geriatric NRI (GNRI), and modified Nutrition Risk in the Critically ill (mNUTRIC) score. Nutritional risk was identified in 27.5% to 100% of participants. The NRS-2002, MNA, MNA-sf, NRI, and MUST demonstrated high sensitivity; the MUST had better specificity. The MNA and MUST demonstrated better criterion validity. The MNA-sf demonstrated better predictive validity for poor appetite and weight loss; the NRS-2002 demonstrated better predictive validity for prolonged hospitalization. mNUTRIC score demonstrated good predictive validity for hospital mortality. Most instruments demonstrate high sensitivity for identifying nutritional risk, but none are acknowledged as the best for nutritional screening in older adults with COVID-19.
Prevalence of anxiety, depression, and stress among teachers during the COVID-19 pandemic A PRISMA-compliant systematic review
(Medicine, 2021) Lima, Severina Carla Vieira Cunha; Silva, David Franciole Oliveira; Cobucci, Ricardo Ney; Andrade, Fábia Barbosa de; https://orcid.org/0000-0001-8268-1986
Background: Identifying the prevalence of anxiety, depression, and stress among teachers during the COVID-19 pandemic. Methods: Systematic review of original studies published in any language. Protocol published in PROSPERO under number CRD42021240543. The search was carried out in the Web of Science, PsycINFO, Pubmed, Embase, LILACS, and SciELO databases, using the descriptors: anxiety, depression, stress, teacher, faculty, COVID-19, and their synonyms. Narrative synthesis was carried out in line with the synthesis without meta-analysis in systematic reviews. Results: Of the 1372 records identified, 6 studies, all cross-sectional, were included in the review. The studies were carried out in China, Brazil, the United States of America, India, and Spain. Five studies included more women than men. The participants were aged from 24 to 60 years. Three studies included only school teachers, 2 included schools and universities teachers, and 1 only university teachers. Of the 5 studies, all dealt with remote activities and only 1 included teachers who returned to face-to-face classes 1 to 2 weeks ago. The prevalence of anxiety ranged from 10% to 49.4%, and depression from 15.9% to 28.9%, being considerably higher in studies with teachers who worked in schools. The prevalence of stress ranged from 12.6% to 50.6%. Conclusion: The prevalence of anxiety, depression, and stress was high among teachers during the pandemic, with great variation between studies. Anxiety and stress were more prevalent in the Spanish study. The results show the need for measures for the care of teachers’ mental health, especially when returning to face-to-face classes.
Prevalência de ansiedade em profissionais da saúde em tempos de COVID-19: revisão sistemática com metanálise
(Ciência & Saúde Coletiva, 2021) Lima, Severina Carla Vieira Cunha; Silva, David Franciole Oliveira; Cobucci, Ricardo Ney; Rachetti, Vanessa de Paula Soares; Andrade, Fábia Barbosa de; https://orcid.org/0000-0001-8268-1986
O objetivo deste estudo é identificar a prevalência de ansiedade em profissionais de saúde durante a pandemia da COVID-19. Trata-se de revisão sistemática de estudos publicados em qualquer idioma em 2020. Foi realizada busca nas bases de dados Embase, LILACS e PubMed utilizando os descritores anxiety, COVID-19, health workers, e sinônimos. A estimativa da prevalência geral de ansiedade com intervalo de confiança de 95% foi calculada utilizando o modelo de efeitos aleatórios. Dos 861 registros identificados, 36 artigos foram incluídos na revisão sistemática e 35 na metanálise. A prevalência geral de ansiedade foi de 35% (IC95%: 29-40). Foi identificado maior risco de ansiedade nas mulheres em relação aos homens (Odds Ratio: 1.64 [IC95%: 1,47-1,84]), e nos enfermeiros, na comparação com médicos (Odds Ratio: 1.19 [IC95%: 1,07-1,33]). Atuar na linha de frente no combate a COVID-19, estar infectado com coronavírus e apresentar doenças crônicas também foram fatores associados com maior risco de ansiedade. Observa-se alta prevalência de ansiedade entre profissionais de saúde, com maior risco entre mulheres e enfermeiros. Há necessidade de medidas que visem sua prevenção, bem como o fornecimento de tratamento precoce e adequado aos com ansiedade moderada e grave.
Selenium in human health and gut microflora: bioavailability of selenocompounds and relationship with diseases
(Frontiers in Nutrition, 2021-06) Evangelista, Karine Cavalcanti Maurício de Sena; Ferreira, Rannapaula Lawrynhuk Urbano; Azevedo, Eduardo Pereira de; Pinheiro, Francisco Irochima; Cobucci, Ricardo Ney; Pedrosa, Lucia Fatima Campos
This review covers current knowledge of selenium in the dietary intake, its bioavailability, metabolism, functions, biomarkers, supplementation and toxicity, as well as its relationship with diseases and gut microbiota specifically on the symbiotic relationship between gut microflora and selenium status. Selenium is essential for the maintenance of the immune system, conversion of thyroid hormones, protection against the harmful action of heavy metals and xenobiotics as well as for the reduction of the risk of chronic diseases. Selenium is able to balance the microbial flora avoiding health damage associated with dysbiosis. Experimental studies have shown that inorganic and organic selenocompounds are metabolized to selenomethionine and incorporated by bacteria from the gut microflora, therefore highlighting their role in improving the bioavailability of selenocompounds. Dietary selenium can affect the gut microbial colonization, which in turn influences the host’s selenium status and expression of selenoproteoma. Selenium deficiency may result in a phenotype of gut microbiota that is more susceptible to cancer, thyroid dysfunctions, inflammatory bowel disease, and cardiovascular disorders. Although the host and gut microbiota benefit each other from their symbiotic relationship, they may become competitors if the supply of micronutrients is limited. Intestinal bacteria can remove selenium from the host resulting in two to three times lower levels of host’s selenoproteins under selenium-limiting conditions. There are still gaps in whether these consequences are unfavorable to humans and animals or whether the daily intake of selenium is also adapted to meet the needs of the bacteria
Systematic review of the association between dietary patterns and perinatal anxiety and depression
(BMC Pregnancy and Childbirth, 2019) Lima, Severina Carla Vieira Cunha; Gonçalves, Ana Katherine; Cobucci, Ricardo Ney; Silva, David Franciole Oliveira; https://orcid.org/0000-0001-8268-1986
Background: Specific dietary factors contribute to greater risks of prenatal and postpartum anxiety and depression. This study aimed to systematically review and assess the evidence regarding the association between dietary patterns and perinatal anxiety and depression (PAAD). Methods: A systematic search of the Latin American & Caribbean Health Sciences Literature (LILACS), PubMed, and Scopus databases for cross-sectional and cohort studies through April 2019 was conducted. The methodological quality of the studies was assessed using the Newcastle-Ottawa scale (NOS) and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework was used to assess the quality of evidence. Results: Ten studies (six cohort and four cross-sectional) were included. All studies had good methodological quality. In these studies, the Western (n = 10), healthy (n = 9), and traditional (n = 7) dietary patterns were examined. The healthy pattern was inversely associated with prenatal and postpartum anxiety and prenatal depression. The traditional Japanese dietary pattern, the traditional Indian-confinement dietary pattern, the United Kingdom traditional dietary and the traditional Brazilian dietary pattern were associated with a lower risk of prenatal depression, postpartum depression, prenatal anxiety and postpartum anxiety, respectively. There was no significant association between a Western dietary pattern and PAAD. The GRADE assessment suggested that the quality of the evidence was very low to low across all outcomes owing to the design, risk of bias, and small sample size. Conclusions: There is no definitive evidence about the relationship between Western dietary patterns and perinatal anxiety and depression. However, it found an inverse association among the healthy dietary pattern and PAAD. Future studies will be required to better evaluate associations between meal patterns and PAAD. Such studies may provide new insights and assist in the development of new prevention and treatment strategies.
Vitamin E levels in preterm and full-term nfants: a systematic review
(Nutrients, 2022) Ribeiro, Karla Danielly da Silva; Assunção, Débora Gabriela Fernandes; Silva, Lorena Thalia Pereira da; Camargo, Juliana Dantas de Araújo Santos; Cobucci, Ricardo Ney; Ribeiro, Karla Danielly da Silva; https://orcid.org/0000-0002-2251-5967
Vitamin E deficiency (VED) is associated with clinical repercussions in preterm newborns (PTN), but low levels are also found in full-term newborns (TN). As this inadequacy can compromise neurogenesis in childhood, studies are needed to assess whether there is a difference in vitamin E status among newborns according to gestational age to provide support for neonatal monitoring protocols. This systematic review presents a synthesis of the available information on the vitamin E status among PTN and TN. The review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Observational studies that evaluated alpha- tocopherol levels were searched in the databases reported in the protocol registered in PROSPERO (CRD42021165152). The Newcastle–Ottawa Scale was used to assess the methodological quality. Overall, 1809 articles were retrieved; 10 were included in the systematic review. In the PTN, the alpha-tocopherol levels ranged from 3.9 to 8.5 mmol/L, while in TN, they were 4.9 to 14.9 mmol/L, and VED ranged from 19% to 100% in newborns. Despite substantial heterogeneity in research methodology and VED classification, the results suggest that the alpha-tocopherol levels among preterm and full-term newborns is below the recommended levels. Our findings demonstrate that further investigations are needed to standardize this classification and to monitor vitamin E status in birth and postnatal with adequate bias control.

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Navegando por Autor "Cobucci, Ricardo Ney"