Navegando por Autor "Cavalcante, Jeferson S."
Agora exibindo 1 - 2 de 2
- Resultados por página
- Opções de Ordenação
Artigo Changes in the suprachiasmatic nucleus during aging: implications for biological rhythms(2013) Engelberth, Rovena C. G. J.; Pontes, André L. Bezerra de; Fiuza, Felipe Porto; Silva, Kayo D. de Azevedo; Resende, Nayra da S.; Azevedo, Carolina Virgínia de M.; Costa, Miriam S. M. O.; Cavalcante, Judney C.; Nascimento Júnior, Expedito S.; Gavioli, Elaine Cristina; Cavalcante, Jeferson S.Animals have neural structures that allow them to anticipate environmental changes and then regulate physiological and behavioral functions in response to these alterations. The suprachiasmatic nucleus of the hypothalamus (SCN) is the main circadian pacemaker in many mammalian species. This structure synchronizes the biological rhythm based on photic information that is transmitted to the SCN through the retinohypothalamic tract. The aging process changes the structural complexity of the nervous system, from individual nerve cells to global changes, including the atrophy of total gray matter. Aged animals show internal time disruptions caused by morphological and neurochemical changes in SCN components. The effects of aging on circadian rhythm range from effects on simple physiological functions to effects on complex cognitive performance, including many psychiatric disorders that influence the well-being of the elderly. In this review, we summarize the effects of aging on morphological, neurochemical, and circadian rhythmic functions coordinated by the main circadian pacemaker, the SCNArtigo Morphological changes in the suprachiasmatic nucleus of aging female marmosets (callithrix jacchus)(Hindawi Publishing Corporation, 2014) Engelberth, Rovena Clara G. J.; Silva, Kayo Diogenes de A.; Azevedo, Carolina V. de M.; Gavioli, Elaine Cristina; Santos, Jose Ronaldo dos; Soares, Joacil Germano; Nascimento Junior, Expedito S.; Cavalcante, Judney C.; Costa, Miriam Stela M. O.; Cavalcante, Jeferson S.The suprachiasmatic nuclei (SCN) are pointed to as the mammals central circadian pacemaker. Aged animals show internal time disruption possibly caused by morphological and neurochemical changes in SCN components. Some studies reported changes of neuronal cells and neuroglia in the SCN of rats and nonhuman primates during aging. The effects of senescence on morphological aspects in SCN are important for understanding some alterations in biological rhythms expression. Therefore, our aim was to perform a comparative study of the morphological aspects of SCN in adult and aged female marmoset. Morphometric analysis of SCN was performed using Nissl staining, NeuN-IR, GFAP-IR, and CB-IR. A significant decrease in the SCN cells staining with Nissl, NeuN, and CB were observed in aged female marmosets compared to adults, while a significant increase in glial cells was found in aged marmosets, thus suggesting compensatory process due to neuronal loss evoked by aging