Navegando por Autor "Bezerra, Mylena Taíse Azevedo Lima"
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Artigo Association between brain morphology and electrophysiological features in Congenital Zika Virus Syndrome: a cross-sectional, observational study(Elsevier, 2020-08) Sequerra, Eduardo Bouth; Rocha, Antonio Jhones Lima da; Medeiros, Galtieri Otavio Cunha de; Moreira Neto, Manuel; Maia, Claudia Rodrigues Souza; Arrais, Nívia Maria Rodrigues; Bezerra, Mylena Taíse Azevedo Lima; Jeronimo, Selma Maria Bezerra; Barros Filho, Allan Kardec Duailibe; Sousa, Patrícia S; Melo, Aurea Nogueira de; Queiroz, Claudio Marcos Teixeira deBackground: Intrauterine infection with the Zika virus (ZIKV) has been connected to severe brain malformations, microcephaly, and abnormal electrophysiological activity. Methods: We describe the interictal electroencephalographic (EEG) recordings of 47 children born with ZIKV-derived microcephaly. EEGs were recorded in the first year of life and correlated with brain morphology. In 31 subjects, we tested the association between computed tomography (CT) findings and interictal epileptiform discharges (IED). In eighteen, CTs were used for correlating volumetric measurements of the brainstem, cerebellum, and prosencephalon with the rate of IED. Findings: Twenty-nine out of 47 (62%) subjects were diagnosed as having epilepsy. Those subjects presented epileptiform discharges, including unilateral interictal spikes (26/29, 90%), bilateral synchronous and asynchronous interictal spikes (21/29, 72%), and hypsarrhythmia (12/29, 41%). Interestingly, 58% of subjects with clinical epilepsy were born with rhombencephalon malformations, while none of the subjects without epilepsy showed macroscopic abnormalities in this region. The presence of rhombencephalon malformation was associated with epilepsy (odds ratio of 34; 95% CI: 2 - 654). Also, the presence of IED was associated with smaller brain volumes. Age-corrected total brain volume was inversely correlated with the rate of IED during sleep. Finally, 11 of 44 (25%) subjects presented sleep spindles. We observed an odds ratio of 0·25 (95% CI: 0·06 - 1·04) for having sleep spindles given the IED presence. Interpretation: The findings suggest that certain CT imaging features are associated with an increased likelihood of developing epilepsy, including higher rates of IED and impaired development of sleep spindles, in the first year of life of CZVS subjects