Navegando por Autor "Bevilaqua, Lia Rejane Müller"
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TCC A importância do profissional bibliotecário como mediador da informação para o desenvolvimento da competência informacional dos usuários com dislexia e transtorno de déficit de atenção e hiperatividade: um estudo de caso na Universidade Federal do Rio Grande do Norte (UFRN)(Universidade Federal do Rio Grande do Norte, 2017) Santos, Rosa Milena dos; Farias, Ronnie Anderson Nascimento de; Bevilaqua, Lia Rejane Müller; Santos, Raimunda Fernanda dosDescreve a importância do profissional bibliotecário como mediador da informação e formador da competência informacional de usuários com distúrbios neurológicos de aprendizagem que, consequentemente, tem necessidades educacionais especiais, no âmbito da Universidade Federal do Rio Grande do Norte (UFRN). Utilizando como cenário da pesquisa a Comissão de Apoio a Estudantes com Necessidades Educacionais Especiais (CAENE) e o Laboratório de Acessibilidade (LA) da Biblioteca Central Zila Mamede (BCZM) nessa instituição. Tem como objetivo geral pesquisar quais as contribuições do bibliotecário para atuar como mediador da informação para usuários com/ou que apresentam distúrbio neurológico de aprendizagem, no qual a CAENE e o Laboratório de acessibilidade da Biblioteca Central Zila Mamede auxiliam na Universidade Federal do Rio Grande do Norte. Tem como objetivos específicos pesquisar as características dos indivíduos com distúrbios neurológicos de dislexia e transtorno de déficit de atenção e hiperatividade nos estudos associados à sua competência informacional e analisar a estrutura curricular do curso de biblioteconomia da Universidade Federal do Rio Grande do Norte com o intuito de avaliar se o profissional bibliotecário tem uma formação profissional que possibilite mediar informação e construir a competência informacional dos usuários com distúrbios neurológicos de aprendizagem. Utiliza como metodologia a pesquisa bibliográfica e exploratória realizando duas entrevistas semiestruturadas com a psicóloga escolar da CAENE e com a bibliotecária-documentalista do Laboratório de Acessibilidade da BCZM. Apresenta como resultado a descrição das funções que o bibliotecário possui como mediador da informação em relação à formação da competência informacional de usuários, principalmente, com distúrbios ou transtornos neurológicos de aprendizagem, além de utilizar estratégias informacionais e tecnologias assistivas para auxiliar, orientar, acompanhar e ajudar os usuários que tenham dificuldades no seu processo de ensino e aprendizagem. Conclui que na estrutura curricular do curso de Biblioteconomia da UFRN do ano de 1998 a 2002 e no ano de 2014 a 2017, faltam disciplinas capazes de formar um profissional bibliotecário que auxiliem em sua formação do profissional em relação a exercer atividades que contribuam para a inclusão informacional, a acessibilidade e a necessidade educacional especial.Artigo Uma abordagem da prova testemunhal a partir da neurolaw(2020-06-29) Pereira, Carlos André Maciel Pinheiro; Bevilaqua, Lia Rejane Müller; Bezerra, Bruno Tavares PadilhaNeste trabalho analisa-se a prova testemunhal no contexto do direito processual civil sob o enfoque da neurolaw. O estudo faz uma breve revisão sobre as características e natureza jurídica da referida prova, focando no testemunho de terceiros que aportam, sob compromisso de dizer a verdade, conhecimento subjetivo pertinente à lide. Utiliza o método indutivo, através de pesquisa qualitativa com suporte em fontes científicas, doutrinárias e legais com o intuito de melhor compreender metodologias que propõe a localização de circuitarias cerebrais relacionadas com o armazenamento de informações específicas e sua relação com a compreensão da prova testemunhal pelos atores do direito. As memórias não são perfeitas e a prova testemunhal é indissociável do processo de evocação da informação adquirida. Debate-se aqui as particularidades e características das memórias para que, quando transmitidas por um testemunho, possam ser devidamente escrutinizadas pelo julgador. Assim a eficácia da decisão judicial será maximizada ao alcançar a verdade material por trás do processo, ao mesmo tempo que salvaguarda a segurança jurídicaArtigo Avoidance memory requires CaMKII activity to persist after recall(2021-11-14) Radiske, Andressa; Gonzalez, Maria Carolina; Rossato, Janine Inez; Apolinário, Gênedy Karielly da Silva; Oliveira, João R. de; Bevilaqua, Lia Rejane Müller; Cammarota, Martín PabloAvoidance memory is destabilized when recalled concurrently with conficting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responsesArtigo BDNF controls object recognition memory reconsolidation(2017) Radiske, Andressa; Rossato, Janine I.; Gonzalez, Maria Carolina; Köhler, Cristiano A.; Bevilaqua, Lia Rejane Müller; Cammarota, Martín PabloReconsolidation restabilizes memory after reactivation. Previously, we reported that the hippocampus is engaged in object recognition memory reconsolidation to allow incorporation of new information into the original engram. Here we show that BDNF is sufficient for this process, and that blockade of BDNF function in dorsal CA1 impairs updating of the reactivated recognition memory trace.Artigo Consolidation of object recognition memory requires simultaneous activation of dopamine D1/D5 receptors in the amygdala and medial prefrontal cortex but not in the hippocampus(2013-11) Rossato, Janine I.; Radiske, Andressa; Kohler, Cristiano A.; Gonzalez, Carolina; Bevilaqua, Lia Rejane Müller; Medina, Jorge H.; Cammarota, Martín PabloThe mesocorticolimbic dopaminergic system includes the ventral tegmental area (VTA) and its projections to the amygdala (AMY), the hippocampus (HIP) and the medial prefrontal cortex (mPFC), among others. Object recognition (OR) long-term memory (LTM) processing requires dopaminergic activity but, although some of the brain regions mentioned above are necessary for OR LTM consolidation, their possible dopamine-mediated interplay remains to be analyzed. Using adult male Wistar rats, we found that posttraining microinjection of the dopamine D1/D5 receptor antagonist SCH23390 in mPFC or AMY, but not in HIP, impaired OR LTM. The dopamine D2 receptor agonist quinpirole had no effect on retention. VTA inactivation also hindered OR LTM, and even though this effect was unaffected by co-infusion of the dopamine D1/D5 receptor agonist SKF38393 in HIP, mPFC or AMY alone, it was reversed by simultaneous activation of D1/D5 receptors in the last two regions. Our results demonstrate that the mesocorticolimbic dopaminergic system is indeed essential for OR LTM consolidation and suggest that the role played by some of its components during this process is much more complex than previously thought.Artigo GluN2B and GluN2A containing NMDAR are differentially involved in extinction memory destabilization and restabilization during reconsolidation(Springer Science and Business Media LLC, 2021-01-08) Radiske, Andressa; Gonzalez, Maria Carolina; Ferreira, Diana Aline Nôga Morais; Rossato, Janine Inez; Bevilaqua, Lia Rejane Müller; Cammarota, Martín PabloExtinction memory destabilized by recall is restabilized through mTOR-dependent reconsolidation in the hippocampus, but the upstream pathways controlling these processes remain unknown. Hippocampal NMDARs drive local protein synthesis via mTOR signaling and may control active memory maintenance. We found that in adult male Wistar rats, intra dorsal-CA1 administration of the non-subunit selective NMDAR antagonist AP5 or of the GluN2A subunit-containing NMDAR antagonist TCN201 after step down inhibitory avoidance (SDIA) extinction memory recall impaired extinction memory retention and caused SDIA memory recovery. On the contrary, pre-recall administration of AP5 or of the GluN2B subunit-containing NMDAR antagonist RO25-6981 had no effect on extinction memory recall or retention per se but hindered the recovery of the avoidance response induced by post-recall intra-CA1 infusion of the mTOR inhibitor rapamycin. Our results indicate that GluN2B-containing NMDARs are necessary for extinction memory destabilization whereas GluN2A-containing NMDARs are involved in its restabilization, and suggest that pharmacological modulation of the relative activation state of these receptor subtypes around the moment of extinction memory recall may regulate the dominance of extinction memory over the original memory traceArtigo Inactivation of the dorsal hippocampus or the medial prefrontal cortex impairs retrieval but has differential effect on spatial memory reconsolidation(2015) Rossato, Janine I.; Köhler, Cristiano A.; Radiske, Andressa; Bevilaqua, Lia Rejane Müller; Cammarota, Martín PabloActive memories can incorporate new information through reconsolidation. However, the notion that memory retrieval is necessary for reconsolidation has been recently challenged. Non-reinforced retrieval induces hippocampus and medial prefrontal cortex (mPFC)-dependent reconsolidation of spatial memory in the Morris water maze (MWM). We found that the effect of protein synthesis inhibition on this process is abolished when retrieval of the learned spatial preference is hindered through mPFC inactivation but not when it is blocked by deactivation of dorsal CA1. Our results do not fully agree with the hypothesis that retrieval is unneeded for reconsolidation. Instead, they support the idea that a hierarchic interaction between the hippocampus and the mPFC controls spatial memory in the MWM, and indicate that this cortex is sufficient to retrieve the information essential to reconsolidate the spatial memory trace, even when the hippocampus is inactivated.TCC A influência das falsas memórias e do same race bias no contexto do processo penal(Universidade Federal do Rio Grande do Norte, 2019-06-21) Rodrigues, Mariana Araújo; Bevilaqua, Lia Rejane Muller; Bevilaqua, Lia Rejane Müller; Clementino, Marco Bruno Miranda; Leão, Paulo Roberto Dantas de SouzaO presente estudo faz uma análise das falsas memórias e do efeito do same race bias no contexto do processo penal. Este trabalho busca demonstrar que, apesar de ser extremamente importante em um contexto legal, as recordações nem sempre reproduzem com fidelidade os acontecimentos vivenciados, uma vez que as memórias podem ser contaminadas por informações relacionadas ou não com um determinado evento em questão. Trata, ainda, sobre o grau de confiabilidade a ser depositado pelo julgador neste meio de prova, que por vezes pode ser o único elemento probatório disponível. Visa a busca pelo aumento da segurança jurídica nesse elemento probandi, com apontamentos de estratégias para diminuir a incidência de falsas memórias e do efeito do same race bias. A metodologia de pesquisa adotada foi a revisão a partir de livros e artigos científicos, sites e jurisprudência relacionados ao tema do estudo. O material estudado permitiu identificar a falibilidade da utilização das memórias como único meio de prova, considerando os princípios constitucionais e processuais penais. Conclui-se que a memória humana é complexa a ponto de gerar elementos de convicção que nunca existiram, podendo ser contaminada até mesmo pelo próprio rito processual, principalmente no contexto da colheita de depoimentos e/ou testemunhos, como possível consequência da falta de orientação dos entrevistadores sobre como conduzir de maneira imparcial os questionamentos.Artigo mTOR inhibition impairs extinction memory reconsolidation(Cold Spring Harbor Laboratory, 2020-12-15) Radiske, Andressa; Gonzalez, Maria Carolina; Ferreira, Diana Aline Nôga Morais; Rossato, Janine Inez; Bevilaqua, Lia Rejane Müller; Cammarota, Martín PabloFear-motivated avoidance extinction memory is prone to hippocampal brain-derived neurotrophic factor (BDNF)-dependent reconsolidation upon recall. Here, we show that extinction memory recall activates mammalian target of rapamycin (mTOR) in dorsal CA1, and that post-recall inhibition of this kinase hinders avoidance extinction memory persistence and recovers the learned aversive response. Importantly, coadministration of recombinant BDNF impedes the behavioral effect of hippocampal mTOR inhibition. Our results demonstrate that mTOR signaling is necessary for fear-motivated avoidance extinction memory reconsolidation and suggests that BDNF acts downstream mTOR in a protein synthesis-independent manner to maintain the reactivated extinction memory traceArtigo Nicotine modulates the long-lasting storage of fear memory(2013) Lima, Ramón H.; Radiske, Andressa; Köhler, Cristiano A.; Gonzalez, Maria Carolina; Bevilaqua, Lia Rejane Müller; Rossato, Janine I.; Medina, Jorge H.; Cammarota, Martín PabloLate post-training activation of the ventral tegmental area (VTA)–hippocampus dopaminergic loop controls the entry of information into long-term memory (LTM). Nicotinic acetylcholine receptors (nAChR) modulate VTA function, but their involvement in LTM storage is unknown. Using pharmacological and behavioral tools, we found that α7-nAChR-mediated cholinergic interactions between the pedunculopontine tegmental nucleus and the medial prefrontal cortex modulate the duration of fear-motivated memories, maybe by regulating the activation state of VTA–hippocampus dopamine connections.Artigo PERK, mTORC1 and eEF2 interplay during long term potentiation: an editorial for 'Genetic removal of eIF2a kinase PERK in mice enables hippocampal L-LTP independent of mTORC1 activity' on page 133(2018-07) Bevilaqua, Lia Rejane Müller; Cammarota, Martín PabloThis Editorial highlights a study by Zimmermann and coworkers in the current issue of Journal of Neurochemistry. The authors' link suppression of PKR-like endoplasmatic reticulum kinase (PERK) activity to eukaryotic elongation factor 2 (eEF2) dephosphorylation and mTORC1-independent high-frequency stimulation (HFS)-induced long-term potentiation (LTP) in acute hippocampal slices from PERK forebrain conditional knockout mice. The results suggest that functional interaction between the signaling pathways controlling different phases of the mRNA translation process is necessary for long-term plasticity in the hippocampus.Artigo PKMζ inhibition disrupts reconsolidation and erases object recognition memory(2019-03-06) Rossato, Janine I.; Gonzalez, Maria Carolina; Radiske, Andressa; Apolinário, Gênedy; Conde-Ocazionez, Sergio; Bevilaqua, Lia Rejane Müller; Cammarota, Martín PabloObject recognition memory (ORM) confers the ability to discriminate the familiarity of previously encountered items. Reconsolidation is the process by which reactivated memories become labile and susceptible to modifications. The hippocampus is specifically engaged in reconsolidation to integrate new information into the original ORM through a mechanism involving activation of brain-derived neurotrophic factor (BDNF) signaling and induction of LTP. It is known that BDNF can control LTP maintenance through protein kinase Mζ (PKMζ), an atypical protein kinase C isoform that is thought to sustain memory storage by modulating glutamatergic neurotransmission. However, the potential involvement of PKMζ in ORM reconsolidation has never been studied. Using a novel ORM task combined with pharmacological, biochemical, and electrophysiological tools, we found that hippocampal PKMζ is essential to update ORM through reconsolidation, but not to maintain the inactive recognition memory trace stored over time, in adult male Wistar rats. Our results also indicate that hippocampal PKMζ acts downstream of BDNF and controls AMPAR synaptic insertion to elicit reconsolidation and suggest that blocking PKMζ activity during this process deletes active ORM.SIGNIFICANCE STATEMENT Object recognition memory (ORM) is essential to remember facts and events. Reconsolidation integrates new information into ORM through changes in hippocampal plasticity and brain-derived neurotrophic factor (BDNF) signaling. In turn, BDNF enhances synaptic efficacy through protein kinase Mζ (PKMζ), which might preserve memory. Here, we present evidence that hippocampal PKMζ acts downstream of BDNF to regulate AMPAR recycling during ORM reconsolidation and show that this kinase is essential to update the reactivated recognition memory trace, but not to consolidate or maintain an inactive ORM. We also demonstrate that the amnesia provoked by disrupting ORM reconsolidation through PKMζ inhibition is due to memory erasure and not to retrieval failure.Artigo Prior learning of relevant non-aversive information is a boundary condition for avoidance memory reconsolidation in the rat hippocampus(2017-09-08) Radiske, Andressa; Gonzalez, Maria Carolina; Conde-Ocaziones, Sergio; Feitosa, Anatildes; Köhler, Cristiano A.; Bevilaqua, Lia Rejane Müller; Cammarota, Martín PabloReactivated memories can be modified during reconsolidation, making this process a potential therapeutic target for post-traumatic stress disorder (PTSD), a mental illness characterized by the recurring avoidance of situations that evoke trauma-related fears. However, avoidance memory reconsolidation depends on a set of still loosely defined boundary conditions, limiting the translational value of basic research. In particular, the involvement of the hippocampus in fear-motivated avoidance memory reconsolidation remains controversial. Combining behavioral and electrophysiological analyses in male Wistar rats, we found that previous learning of relevant non-aversive information is essential to elicit the participation of the hippocampus in avoidance memory reconsolidation, which is associated with an increase in theta and gamma oscillations power and cross-frequency coupling in dorsal CA1 during reactivation of the avoidance response. Our results indicate that the hippocampus is involved in memory reconsolidation only when reactivation results in contradictory representations regarding the consequences of avoidance, and suggest that robust nesting of hippocampal theta-gamma rhythms at the time of retrieval is a specific reconsolidation marker.