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Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review
(Taylor & Francis, 2022) Morais, Ana Heloneida de Araujo; Nascimento, Amanda Maria de Souza; Oliveira Segundo, Victor Hugo de; Aguiar, Ana Julia Felipe Camelo; Piuvezam, Grasiela; Passos, Tha ıs Souza; Damasceno, Karla Suzanne Florentino da Silva Chaves; http://lattes.cnpq.br/1233944493334651
This systematic review (SR) aimed to gather studies describing the antibacterial action mechanisms and mode of trypsin inhibitors. The review protocol was registered (PROSPERO: CRD42020189069). Original articles resulting from studies in animal models, in bacterial culture, and using cells that describe antibac terial action of trypsin inhibitor-type peptides or proteins were selected in PubMed, Science Direct, Scopus, Web of Science, BVS, and EMBASE. The methodological quality assessment was performed using the PRISMA and OHAT tool. 2382 articles were retrieved, 17 of which were eligible. Four studies demon strated the action mechanism directly on the bacterial membrane, and the fifth study on endogenous pro teases extracted from the bacteria themselves. The antibacterial action mode was presented in the other studies, which can generate bacteriostatic or bactericidal effects without describing the mechanisms. This study generated information to enable new preclinical or clinical studies with molecules contributing to public health.